I read around and I like this PegMGF taken immediately post w/o and the igf 2 days later. So say my pet monkey lifts weights M chest arms shoulders W Legs (monkey squats) F Back and light arms (swing from trees with dumbbells) you do PegMGF post w/o and IGF MWF (?on the igf?). So 40mcg IGF MWF and 100 to 200mcg MWF PegMGF......
Here's some info that seems to support this dosing.
MGF is markedly up-regulated in exercised and damaged muscle. Therefore the most effective time to administer it is immediately post work out. If you happen to have administered it a day or two before your workout, and this is especially true of the PEG version, it simply is going to float around the body and may hopefully find its way to the target receptor where damage occurred. This clearly is less effective. If you shoot it locally right after exercise, what happens? It gets up-regulated quickly where it is needed to begin recovery.
MGF has a distinct activity compared to that of mature IGF-I in that it can increase myoblasts proliferation, but it totally inhibits the myotubes formation. This intuitively makes sense, since repair is prioritized over growth. The important thing to note here is that growth will follow, but only if MGF is not present. Evidently, and this may vary based on a host of factors, that MGF detection levels peak at 0-24 hrs post injury and regress to day zero levels by day 7 when its work is done. See 'Expression & Splicing...' article below.
It is interesting to note that after 0-1 day the decrease in MGF expression is accompanied by a reciprocal increase in IGF-IEa. This indicates that, following mechanical stimulation or muscle damage, the IGF-I gene is first spliced to produce MGF and then later to produce the more common IGF-IEa transcript. It would therefore make most sense, that exogenous IGF be introduced after at least a day or more of MGF administration.
Certainly MGF and IGF can be taken weeks apart, but let's not forget that in the natural body, binded IGF is present at most times to unbind and muscle expressed IGF released to attach to needed receptors shortly after MGF is cleared. Furthermore, IGF is needed to close the loop for growth more so 3 days after damage. For me, the logical thing to do is to take IGF 3-5 days after MGF administration in the same area that you trained. This therefore presents a staggered MGF-IGF cycling.
For example, if you worked out biceps on day 1, shoot MGF directly to the biceps post-workout and wait 3-5 days before shooting IGF in the biceps. This can go on across all muscle groups where you inject MGF. To make this work youï¿½??ll need to keep a log so you know what to inject where and when.
MGF shows greater proliferative rates of mononucleated myocytes than cells transfected with IGF-1Ea. The point here is that IGF-1 expressed by muscle is also understood to do what MGF does, i.e. to activate satellite cells, though at a much lower rate. So IGFr3 taken immediately post work is least effective. Not forgetting that our body will have naturally manufactured MGF post-workout therefore inhibiting IGF's ability to proliferate anyway. And as far as IGFï¿½??s functionality to fuse cells is concerned, well that ainï¿½??t gonna happen until proliferation has subsided after a few days when MGF has done its work.
Hope this helps.