It's only a gap of 9.5 hours, if you think about it. But what's the issue? You can't find a glass of water between 4:30 and 6:30pm? The capsules travel well; stick a couple in a pocket (wrap them in some tinfoil if you want) and take them with you.
YMMV (Your Mileage May Vary), depending on age and natural T-levels (and other factors such as stress. I'm 46 and feel different within a couple weeks. Pay attention to the cycling suggestions on the bottle.
Nothing overt or quantifiable. I think I feel more "up" for workouts, but I also use Power Drive, which has a lot to do with that.
I don't think there are any negative side-effects to worry about, if that's on your mind.