bingo, Trestolone converts to 7α-Methylestradiol - Wikipedia
Estradiol also lowers blood pressure in several animal models of hypertensive, including SHR [63], stroke prone SHR (SHRSP; [64]), rats with deoxycortisterone acetate-salt induced hypertension [65], Dahl salt-sensitive rats [66] and rats with pulmonary hypertension [67,68]. In contrast, ovariectomy does not affect the development of hypertension in SHRs [6], suggesting that the effects of estradiol on blood pressure in rats are pharmacological rather than physiological. Unlike the natural estrogen estradiol, the synthetic estrogen ethinyl estradiol increases blood pressure [55], suggesting that the effects of natural and synthetic estrogens differ markedly and may influence distinct mechanisms involved in the regulation of blood pressure. For example, even though contraceptive estrogens are administered at a lower dose (30–200 μg) than estrogens (0.625–2 mg) used for hormone replacement therapy, contraceptive estrogens increase blood pressure [55].
Kind of important which estrogen that trestolone is aromatized to.