High SHBG on TRT, Frequency?

Pharma / TRT Testosterone Replacement
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Question, is this from a published study? If so, I’d love to have the reference for the source. If this indeed the case, it does make sense to me. SHBG is a protein that binds and protects T from liver metabolism. Unfortunately, it also binds and prevents it from crossing the blood-brain barrier, which is the main problem those of us with very high SHBG (e.g., 90-100 range).

Since SHBG protects T from liver metabolism, it would make sense that those with higher SHBG levels have higher TT at a given dose (or rate of production in naturals). However, that is why TT is a very misleading lab test in individuals with high SHBG. A much better indicator of health is free or bioavailable T. These tests are a better measure of functioning T within the body.

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I’m not sure I’ve seen it referenced in a study, but it’s in lots of blood work I’ve seen, and it does make sense as SHBG is storage along with transport. The more that SHBG kept T in serum the higher TT will be

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Ppl keep saying our ancestors had higher TT than we do, and they’re probably right, but their diet would have meant higher SHBG too, like we see in Keto/Carnivore advocates. So the FT, I imagine, would be similar

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