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Wyeth Clinical Trials

Who else is waiting for the wyeth trial results of myo-029? The first trial results are stated as being out by the end of this year.

Yes, that should prove very interesting. But, if successful I doubt that it will be obtainable by the average Joe.

Any news yet? I understand the analysis of the data began last year (2006) in November.

Myostatin blocking is hugely interesting. But the biggest question in my mind is what are the side effects of blocking this protein from binding. I’ve read where some people believe it would “deplete muscle stem cells”, but somehow that doesn’t make sense to me (or, most likely, I am just not understanding completely how it all works).

http://images.t-nation.com/forum_images/2/f/2f64f-muscle_dog.jpg

Regulation of muscle growth by multiple ligands signaling through activin type II receptors. Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18117-22.

Direct quote from results section:

We then examined the ability of ACVR2B/Fc to enhance muscle growth in vivo. Female C57BL/6 mice beginning at 6 weeks of age were given five i.p. injections of ACVR2B/Fc over a span of 4 weeks at a dose of 10 mg/kg per injection. We compared muscle weights in these mice with those of control mice that had received the same schedule of injections of PBS. Injections of ACVR2B/Fc caused increases in muscle growth by 32�??40%, an effect that was highly significant (P values ranged from 10-7 to 10-8). The effect of ACVR2B/Fc on muscle growth was rapid, with the maximal effect being reached after only two injections spaced 1 week apart. The effect was also dose-dependent, and at the highest dose (50 mg/kg), we were able to achieve muscle mass increases of 39�??61% after just 2 weeks. These findings demonstrate that the capacity for increasing muscle growth by interfering with this signaling pathway is significantly larger than previously appreciated.

Wow, amazing! If this carried over to humans, bodybuilding would be changed forever. I can’t wait to see when something like this would be available to humans. It would be worth the money. An injection like this also sounds more appealing than the intraveonous drip of myo-029.

Imagine if you could look as muscular as this with no training and no special diet:


And this:

[quote]big balls wrote:

Imagine if you could look as muscular as this with no training and no special diet:[/quote]

Does this bother anyone else? Sure the final result is great, but the journey there is basically our passion. Imagine if we didn’t need to work out to achieve our ideal bodies, I would still feel so unsatisfied. And not to mention, any Average Joe could achieve what we do to differentiate ourselves from them from a couple of injections. Everyone walking around would be jacked. That would kinda suck.

Yeah but…

I would still train but not focus on bodybuilding but performance, strength training. Could you imagine how easy physical labour would be.

If this doesn’t appeal to you: massive increase in muscle size and no fat gain then you are not a bodybuilder. Just think steroids, modern bodybuilding depends on them, absolutely depends on them.

[quote]Reef wrote:
big balls wrote:

Does this bother anyone else? Sure the final result is great, but the journey there is basically our passion. Imagine if we didn’t need to work out to achieve our ideal bodies, I would still feel so unsatisfied. And not to mention, any Average Joe could achieve what we do to differentiate ourselves from them from a couple of injections. [/quote]

To some degree, but, ass with no work ethic or motivation hiding under layers of unearned myostatin-inhibited muscle is still an ass with no work ethic. I’m willing to bet the differentiation will still be visible from those who use it in addition to training.

Even if it is totally successful, they will just end up like piedmontese cattle, awkard, unathletic, and useless. Piedmontese cattle(the “double-muscled” animals) aren’t used to pull carts, they have such a low level of activity their bones would snap and the useless muscle distorting the break point would make recovery impossible.

Very interesting. Will definitely be watching for the results of Wyeth’s clinical trials.

Hi, New here 1st post… You could look at it from this (my) view. People with bad injuries (me with broken back from car accident, not paralyzed) could benefit from it. I have to be very careful when training and can only target certain areas, I would like to try something like that.

I like how Mark sees it in a way. I mean take Dave Tate for example, He’s torn his pecs countless times and because cannot build a truly perfect physique. With this, a hardworking man that deserves it, the injections could bring fairness that life lacks at times.

[quote]Tulkastaldo wrote:
Reef wrote:
big balls wrote:

Does this bother anyone else? Sure the final result is great, but the journey there is basically our passion. Imagine if we didn’t need to work out to achieve our ideal bodies, I would still feel so unsatisfied. And not to mention, any Average Joe could achieve what we do to differentiate ourselves from them from a couple of injections.

To some degree, but, ass with no work ethic or motivation hiding under layers of unearned myostatin-inhibited muscle is still an ass with no work ethic. I’m willing to bet the differentiation will still be visible from those who use it in addition to training.

Even if it is totally successful, they will just end up like piedmontese cattle, awkard, unathletic, and useless. Piedmontese cattle(the “double-muscled” animals) aren’t used to pull carts, they have such a low level of activity their bones would snap and the useless muscle distorting the break point would make recovery impossible.
[/quote]

I agree with some of your points, but not that a “myostatin blocking” (so to speak) using athlete or bodybuilder would be awkward and unathletic. I don’t think that would be true at all.

[quote]Tulkastaldo wrote:
Reef wrote:
big balls wrote:

To some degree, but, ass with no work ethic or motivation hiding under layers of unearned myostatin-inhibited muscle is still an ass with no work ethic. I’m willing to bet the differentiation will still be visible from those who use it in addition to training.

[/quote]

I agree. I think once people are able to use this stuff, yes, the average non-training Joe would look a bit more jacked; however, with additional stimulus provided by training, the gains would be substantially increased.

Would LOVE to try some (whenever it becomes available…on the black market of course!)

Johns Hopkins’ Se-Jin Lee recently found that overproduction of one myostatin inhibitor pumps the mice up even more than previous results instead of 60% up to 81 percent in females and a whopping 116 percent in males. Results of human clinical trials are pending.

Interesting.

It would be a big boon for someone with muscle wasting diseases, AIDS comes to mind as does any debilitating sickness (malaria, dengue etc). On the downside, longer lifespans it would produce would be quite the burden on the economy and food production.

And even though the avg joe would look better, a guy who lifts as well would look even better with this.

It’ll probably be tightly regulated though, because we all know how the govt loves to play mommy and tell us whats right or wrong

I think this is a good thing, those who don’t want to work will look good and those want to work will look incredible.

As fast as science can come up with new pills for weight loss and muscle building, the average American will come up with new ways of making themselves fatter and more unhealthy even faster.