This is largely my understanding of the issue. However I will add a couple more points:
T is also a part of the negative feedback loop, so elevated T (and probably other androgens, but don’t quote me) is still going to cause shutdown, even in the presence (or absence) of E2/SERMs.BBB[/quote]
Yes, other androgens in addition to T will definitely cause that negative inhibition.
I believe nolva is associated with reduced protein synthesis.
Nolva has definitely been shown to decrease IGF-1 levels. I don’t know if other SERMs don’t, or if they just haven’t been examined as closely. Not sure if the IGF-1 decrease is systemic (liver produced) or if it’s also mirrored in IGF production in skeletal muscles.
I know that GH and related peptides definitely help me greatly in PCT; whether it’s due to countering the drop in IGF, or to other factors, I can only guess.[/quote]
I recently read something similar and was debating running IGF-1 Lr3 in my post cycle. Any thoughts on this? I haven’t found many who have done this but it seems like a great addition to pct.