I realize there have been very few studies done on men on TRT, and most answers for these questions would be speculation. None the less, I'm wondering...
If hCG is used to prevent testicular atrophy and subsequent replacing of testicle tissue with scar tissue, what permanent changes can occur because of TRT? HCG would switch the shutdown from the testicles to the pituitary, correct? Can permanent changes occur in the pituitary? If so, would there be a benefit to discontinuing TRT for a few weeks every 12-16 weeks, and then taking nolvadex? I would think that restarting pituitary LH output for a month every four months would help keep the pituitary healthy. The purpose of this would so that if TRT needs to be discontinued for whatever reason (for example, fertility reasons), there would be a greater chance of a successful restart.
If hCG is taken with TRT, would there be shutdown anywhere besides the pituitary? From what I understand, hCG allows for almost normal testicular function. Is it possible that the differences between hCG, and endo LH and FSH could cause permanent changes in the testicles.
I believe the permanence of TRT is overstated. There was a birth control study done in China, in which eugondal men were given testosterone only TRT at, if I remember correctly, 200mg per week for 2.5 years. In the study, 95% of the men resumed normal testosterone production after several months.
I don't plan to start TRT until I'm at least 30, and until I've cryo-ed some sperm. But, I'd like to learn about it now.