I’ve been looking into whether IGF-1 should be incorporated into PCT, during a cycle, or before a cycle.
My initial thinking was before a cycle, for 2 main reasons. First and foremost, since IGF-1 increases satellite cell activity, and myogenic differentiation, I would think that it would be more useful to do this before your cycle, and then use the cycle to encourage growth in the new muscle. Secondly, I know that there is a direct correlation between testosterone levels and GH, which in turn spurns IGF-1 production. My initial thinking was this: since an exogenous source of IGF-1 would encourage downregulation of the receptors, by increasing test levels to superficial levels, one could �??overshoot�?? the downregulation, at least for a short period of time. What I mean by this is, since the downregulation is already taking place, increasing the amount of test in the body, and thus the amount of GH, and thus IGF-1, you would still have enough to activate the receptors, despite the downregulation.
However, I got to thinking once again. For starters, wouldn�??t downregulation for such a long period of time be hard to recover from. Granted, I�??ve heard of pMGF being used as a �??PCT�?? for IGF-1, although I know nothing about pMGF, so I can�??t comment on it. However, my thinking was still the same, that it would be hard to recover. My thinking soon switched, regarding my thoughts on when to use IGF-1. Mainly, I don�??t feel there would be much downregulation in the period where the exogenous test is used. Granted, the test itself is exogenous, but it�??s affects on GH levels should be endogenous. Once again, let me try to explain myself. Although the test itself is exogenous, it would increase production of endogenous GH. As such, it is my personal belief (no, I really don�??t have much proof of this) that an increase in endogenous sources of hormones causes little to no shutdown/downregulation.
Because of this, it would make sense to use the IGF-1 AFTER the cycle, because your body would not be producing the same amount of IGF-1 as before, but (at least in my belief, which I am quick to acknowledge has no scientific backing) would not be as severely shutdown/downregulated. Secondly, I was reading through PubMed and found this excellent piece of advice regarding IGF-1. �??two boys aged 10 and 14 but prepubertal and one 28-year-old fully sexually developed adult. IGF-I was administered by a once daily subcutaneous injection of 150 microg/kg per day to the boys and 120 microg/kg per day to the adult patient…In the two older boys and the adult patient, there was a progressive rise in luteinizing hormone, follicle-stimulating hormone and testosterone.�?? Granted, these were GH resistant people, but regardless, I still feel that the effects could be seen in those recovering from a cycle.
Anyone have any thoughts on the subject? This is my first time really trying to come up witih my own research, and not just listen to what I�??m told. If it�??s completely incorrect, please point out where I went wrong, obviously I�??m in this to learn.
By the way, the study cited was from here…
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&dopt=AbstractPlus&list_uids=9506862