T Nation

Why Doesn’t Anastrozole Work as an AI to Decrease Estradiol?


#1

I began a HCG treatment plan called the Boost Program at LowT 99. The goal was to attempt to raise my testosterone above +1,000, decrease the estradiol to 20-30, and reach an optimal range of testosterone to estrogen with a ratio above 30:1.

Conclusion:
The Anastrozole had absolutely no effect as an aromatase inhibitor. After 3-4 months on the Boost Program, my testosterone increased from 671 to 1,313 (+95.68%), however, the estradiol increased from 38.0 to 126.0 (+231.58%). After increasing the dosage of Anastrozole from 0.25 mg/wk to 5.0 mg/wk there was still no decline in the estradiol levels. I decided to quit the program entirely after the third cycle and lab results.

Age: 32
Height: 5’9’’
Baseline hormone levels before beginning the Boost Program
Date: 3/27/2018
Weight: 146.0 lbs
Testosterone: 671 ng/dL
Estradiol: 33.8 pg/mL
SHGB: 63.6 nmol/L
Testosterone/Estradiol Ratio: 17.66 to 1

Boost Program: The medication that I was prescribed and routine

First Cycle:
DHEA – Dosage 20mg daily
Clomid - Dosage: 25mg daily
HCG: Human Chorionic Gonadotropin Dosage: 0.5mL twice per week
Anastrozole Dosage: 0.25mg 1 cap per week

Lab Results: 5/11/2018
Weight: 155.0 lbs
Testosterone: 1,126 ng/dL
Estradiol: 100.4 pg/mL
SHGB: 46.3 nmol/L
Testosterone/Estradiol Ratio: 11.22 to 1

Second Cycle:
DHEA - Dosage: 20mg daily
Clomid - Dosage: 25mg daily
HCG: Human Chorionic Gonadotropin - Dosage: 0.5Ml twice per week
Anastrozole - Dosage: 0.50mg 3 caps per week

Lab Results: 6/13/2018
Weight: 168.0 lbs
Testosterone: 1,308 ng/dL
Estradiol: 109.7 pg/mL
SHGB: 56.7 nmol/L
Testosterone/Estradiol Ratio: 11.92 to 1

Third Cycle:
DHEA - Dosage: 20mg daily
Clomid - Dosage: 25mg daily
HCG: Human Chorionic Gonadotropin - Dosage: 0.5Ml twice per week
Anastrozole - Dosage: 1.0mg 5 caps per week

Lab Results: 7/24/2018
Weight: 177.2 lbs
Testosterone: 1,313 ng/dL
Estradiol: 126.0 pg/mL
SHGB: N/A
Testosterone/Estradiol Ratio: 10.42 to 1

Conclusion:
The Anastrozole had absolutely no effect as an aromatase inhibitor. After 3-4 months on the Boost Program, my testosterone increased from 671 to 1,313 (+95.68%), however, the estradiol increased from 38.0 to 126.0 (+231.58%). After increasing the dosage of Anastrozole from 0.25 mg/wk to 5.0 mg/wk there was still no decline in estradiol levels. I decided to quit the program entirely after the third cycle and lab results.

Is there any other way that I can suppress the estradiol levels and prevent them from increasing with testosterone levels rising? I’m disappointed that Anastrozole was ineffective. Will Resveratrol or DIM (estrogen blockers) produce better results than Anastrozole (AI)?


#2

The reason why the anastrozole didn’t lower your estrogen is because it can’t effect estrogen being produced inside your testicles and means the HCG dosage was too high for you, the only way to lower estrogen in this case is to lower the HCG dosage.

This is another example why it’s important to be working with an experienced doctor. Also men should be using the Sensitive E2 test LC/MS method designed for men, any other test is invalid. TRT will do a better job of lowering your SHBG freeing up more Free T.

Also HCG suppresses the top half of the testicles while stimulating the bottom half, it’s why it’s rate of success is so low compared to TRT.


#3

I will agree with Systemlord and add that you were doing everything that aromatases very easily in men…DHEA, Clomid, HCG…you were on a basic trifecta of aromasing compounds and otherwise overdosed on them. 25mg Clomid/Day is way too much. That’s problem number one. Should be more like EOD or E3D, or 12.5mg/D something like that. Clomid is a notorious E producer when overdosed.


#4

I’m on 25mg of clomid ED as well. And .3mg of arimedex ED. The protocol got rid of my fatigue completely rite now I’ve been up sense 6am and it’s now 1am the next day and I’m still not tired. Before this could not even be possible for me. But here’s something I don’t understand. I have been gaining a lot of fat in my stomach and I am only 150 pounds 5"10 so I’m pretty skinny and I just turned 30 so I don not know where this belly fat came from and its a lot. So I really need to fix this problem


#6

Wow 146 to a 177 ponds is a great amount of weight in such a short period of time. Like I would love nothing more to gain weghiit but healthy weight and for it to be eventually distributed through my body and not just my stomach. Yea I get hormone levels ch eked every month and my E2 came in at 11pg range (>29). So my E2 is way too low. My protocol is 25mg clomid ED and .3mg A.I everyday.

I have another question why did you take HCG and clomid together???


#7

Of course it did. You’re running a protocol that looks like it was put together by a doctor who got his degree from Hollywood Upstairs Medical College. This is why even the dumbest doctors use testosterone for testosterone replacement therapy. I’m curious, how much are you paying these people to f**k up your body?


#8

I took HCG and clomid together because it was part of this program offered at LowT99 called the Boost Program. My testosterone levels were naturally normal before starting the Boost program and I just wanted to raise them above 1,000ng. HCG stimulates natural testosterone production is a less extreme alternative to Testosterone Replacement Therapy (TRT).

What is your exact estradiol level? The response indicates that it was above 29, but does not provide the exact number.


#9

I discontinued the program after 3.5 months. The company is called Low T99. The Boost Program (HCG) actually costs more at $179/mo compared to the Testosterone Replacement Therapy (TRT) program priced at $149/mo.

To iron_yuppie: I just wanted to raised my testosterone levels above 1,000ng while decreasing the estradiol to within 20-30. Under the Boost Program that I tried, the Anastrzole (aromatase inhibitor) was completely useless at preventing estradiol levels from increasing when my testosterone levels increased. Do you know of a more efficient treatment option?


#10

Of course the anastrozole didn’t work, it doesn’t do what they prescribed it for. You could have taken pills made of taco seasoning and gotten the same effect. This is why hCG monotherapy is not the first treatment choice. A more efficient treatment option for testosterone replacement is…wait for it…testosterone.


#12

LOL you got me at he could of taken Pills made of Taco seasoning. Iron you’re good fun haha.


#13

Are you saying that Anastrazole is more effective as an aromatase inhibitor for testosterone replacement therapy and less effective when used with HCG? If so, I’ve come across another individual that used HCG and Anastrazole effectively together for decreasing estradiol and increasing testosterone.

In regards to testosterone replacement therapy, I would only consider using that method if my natural testosterone levels fell below 400-500ng. Hopefully I won’t need to resort to TRT until after reaching 40-years-old.


#14

Also sorry to hear about your situation EricTest. I can’t imagine experiencing tons of Estrogen increase. There is this supplement called CALCIUM D-glucarate, it rids all Toxins in body, especially Estrogen & Xenoestrogens from plastics, some guys take 500MG of it while on T.R.T it might just bring down your estrogen. Don’t count what i said though. All the best dude.


#15

THIS is from BulletProof Coffee founder Dave Asprey!.

In one study, calcium-d-glucarate was able to reduce the number of estrogen receptors by 48 percent. It’s also been shown to lower serum estrogen levels by 23 percent. High estrogen is also a problem for men. Whether your a man or woman, calcium-d-glucarate will help maintain proper hormone balance.

Also will depend on your own personal Metabolism too. If you did Decide too buy & try. can report back some Good news with it.


#16

I’ll read up on CALCIUM D-glucarate. I’ve also heard about Diindolylmethane (DIM) and Resveratrol to bring down estrogen levels too. Not sure how effective they are.


#17

Calcium with DIM combined, both at 500mg Dose each, should 100% do the Job. if it was me, and i wanted a more Natural Approach than drugs, i would use both of those at 500mg each. u welcome man.


#18

It doesn’t work for intratesticular aromatization, which is what happens with hCG. Have you tried Clomid monotherapy? Seems promising. Look into it and see what you think. I


#19

What supplement or Drug Iron brother, actually reduces Testicle estrogen then Do you know? otherwise how would a man reduce it if gets too much in the testes.


#21

None that I know of.


#22

34:00-46:00 Dr. Rouzier states that suppressing rising estradiol with Anastrazole results in abdominal fat, loss of bone density, development of prostate cancer, etc. This contradicts what most trt specialists, endocrinologists, and related health professionals believe.


#23

Just got my lab results last week

Prior to treatment 12/15/18 Testosterone 847, Estradiol 35, T/E Ratio: 24:1

First Cycle: 3 weeks: 500 IU HCG troche (3) per week, No Chlomid, 1.0mg Anastrazole (1) per week
Lab Results (Lab Corp.):
Testosterone 885
Estradiol 24
T/E Ratio 37:1
How do I feel? I don’t notice much of a difference at all with the HCG troche. I prefer the injectable HCG.

Second Cycle: 3 weeks: Switching to HCG Injections 500 IU (2) per week, Chlomid 12.5mg every day, Anastrazole same does at 1.0mg (1) per week.
Lab Results: To be determined…