This is from another board, but I thought it would make interesting discussion:
I am aware of most of the mechanisims involved here but i would really like to discuss this a little further as i couldn't really find any other indepth threads regarding the subject.
I have noticed allot of people trying to restart after failing TRT, the big question is - why is this? Why do people describe a roller-coaster ride when referring to testosterone levels? Could adrenals be causing the mood swings, poor mood, etc?
When i did injections the last time (125mg weekly), i ended up feeling worse in the libido/ED/Shrinkage department than before. I felt a little stronger, maybe a little sharper mentally and didn't have as many muscles aches and pains. In most aspects i did see "some" improvements but nothing outrageous. However the ED was absolutely terrible, allot worse than before and i had times where i simply couldn't get erections. Even now they are hard to get, but some times allot better than others.
I am aware that testosterone does the following:
1) Can raise total testosterone too high resulting in excess Estridol due to armotization.
2) If a person is low on thyroid hormone and high E2 is introduced, this will further down-regulate the effects of thyroid hormone due to recepter competition.
4) Supressing adrenals (ATCH/LH) will down-regulate DHEA and Progesterone production.
Does this mean everyone doing TRT should be doing full HRT? Should everyone be treating themself with Melrom/HC and thyroid?
Are perfect responders to TRT people with no outstanding adrenal fatigue and hypothyroidism?