In males, LH–[testes]–>pregnenolone–[adrenals]–>progesterone
The pregnenolone–>progesterone process in the adrenals is not influenced by LH.
“”“Progesterone is produced in the ovaries (by the corpus luteum), the adrenal glands (near the kidney), and, during pregnancy, in the placenta. Progesterone is also stored in adipose (fat) tissue.”""
This is interesting:
Micrograph showing changes to the endometrium due to progesterone (decidualization) H&E stain.
Progesterone exerts its primary action through the intracellular progesterone receptor although a distinct, membrane bound progesterone receptor has also been postulated. In addition, progesterone is a highly potent antagonist of the mineralocorticoid receptor (MR, the receptor for aldosterone and other mineralocorticosteroids). It prevents MR activation by binding to this receptor with an affinity exceeding even those of aldosterone and other corticosteroids such as cortisol and corticosterone.
Progesterone has a number of physiological effects that are amplified in the presence of estrogen. Estrogen through estrogen receptors upregulates the expression of progesterone receptors.[26
- above that progesterone can block cortisol receptors. - easier to sleep
- and an implication that low E2 could tend to reverse the above effects