Physiological data and clinical outcomes demonstrate that bioidentical hormones are associated with lower risks, including the risk of breast cancer and cardiovascular disease, and are more efficacious than their synthetic and animal-derived counterparts. Until evidence is found to the contrary, bioidentical hormones remain the preferred method of HRT. Further randomized controlled trials are needed to delineate these differences more clearly.
"Synthetics refer to man-made hormones, as you’d expect — hormones that are made from chemical sources that approximate the hormones the human body makes. "
" What are Natural Forms of HRT? In most discussions of HRT, “natural” refers to estrogens and progesterone that are often man-made, but from natural plant sources. Most of them are naturally occurring and in theory, bio-identical to the hormones your body makes. In other words, they don’t approximate your hormones; they have the same exact chemical structure
Most bio-identical hormones come from natural plant sterols that are derived from soy and/or wild yams. Plants such as soy and wild yam have pre-cursor molecules known as “phyto-hormones” that can be easily converted into bio-identical hormones such as estrogen, progesterone, testosterone, etc. These are taken to a laboratory where they are converted chemically, or semi-synthesized to hormones that are identical and indistinguishable from the body’s own.
What is the difference between bio-identical hormones and synthetic hormones?
From a physiological perspective, bio-identical hormones derived from natural plant sources are identical to those that the body produces for itself, in physiological proportions. When we are “replacing” the body’s hormones, we feel it makes more sense to use entities which the body recognizes as its own, rather than hormones from horses, imbalanced versions or overly potent synthetic versions. Synthetic hormones are chemically altered to be many more times potent than natural, bio-identical hormones.
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