I know I'm a non responder because I don't put on any water weight while supplementing with it. Also, I make steady strength and size gains when im supp'in with it or not. Sometimes I just won't have any around to use and I'll be too lazy to go buy some. However, like i said, i don't experience any difference in performance or results in the gym. I still try to use it all the time because theres so much science behind it and its really affordable.