Here is what my doctor gave to me. And then he said “20 gms? I would not worry about it.”
essentially, large dosages can theoretically cause lowered serotonin and dopamine levels.
SUMMARY ï¿½?? BCAAs are a primary component of muscle, accounting for over one-third of all amino acids in muscle protein. Muscle tissue demonstrates an increased need for these amino acids during times of physical stress and intense exercise. In addition, these amino acids may help preserve and/or restore muscle mass in individuals following surgery or trauma.
PHARMACOLOGY ï¿½?? As with any amino acid, the primary function of the BCAAs is to allow synthesis of proteins. In addition, they may be catabolized to serve as an energy source. In particular, they may be used directly by skeletal muscle, as opposed to other amino acids which require hepatic gluconeogenesis to generate useful metabolic currency. Since branched-chain amino acids may be metabolized by peripheral muscle tissues, supplementation may decrease the rate of protein catabolism under stress (such as in infection and trauma). This will assist in maintaining a balance between serum concentrations of these agents and aromatic amino acids.
TOXICITIES, WARNINGS, AND INTERACTIONS ï¿½?? No known toxicity or serious side effects reported. BCAAs compete with the aromatic amino acids for entry into the brain. Since aromatic amino acids are used in the synthesis of neurotransmitters, ingesting large doses of BCAAs may result in a decline of brain levels of serotonin and dopamine. Increased mortality has been documented in individuals with ALS.
SYMPTOMS OF DEFICIENCY ï¿½?? Use with caution in individuals with renal or hepatic failure. Human deficiencies are rare. Severe valine deficiency is reported to cause neurological defects. Isoleucine deficiency may cause muscle tremors. There are no reports of leucine deficiencies.
Drug/Nutrient Interactions: Antidiabetic drugs
Nutrient/Nutrient Interactions: The branched-chain amino acids (leucine, isoleucine, valine) compete with the aromatic amino acids (phenylalanine, tyrosine, tryptophan) for transport into the brain.