By the way still really really early. I am feeling weird, I feel less wired physically. At the same time I am over come with more emotions I have to juggle, I guess it comes with E2 as it goes back to baseline on 100mg and no AI.
But no way in hell can I inject more and more T without AI like its all good.
Example from the 1970s:
Circadian TT fluctuationâŠ
Notice subject SFD. He is at the âpinnacle of manlinessâ, when men were men in terms of TT levels.
Hereâs his daily variation with respect to max TT every dayâŠ
Notice anything strange?
Yes, correct. SFDâs INTRADAY PEAK is what many today have for a WEEKLY TROUGH (200-250 mg/week TC E7D):
Danny and TOT World either donât get it or purposely misleading people.
Eugonadal guys always in the green shaded region. TOT Land many times may only touch the ceiling of the green shaded region.
âŠ
[quote=âtareload, post:1, topic:277585â]
TLDR (great suggestion by @kazuya_mishima1):
Danny and the TOT folks are mistaken to put it politely with respect to pharmacokinetics and dose response of injectable exogeneous testosterone. They act like itâs some mystery how you will respond to injectable testosterone. It really isnât and we can put a very confident estimate on it. Many guys running TOT protocols (150+ mg/week) are way above physiologic levels all week long 24 hours a day. Read on if youâd like to understand with an example in excruciating detail. Pay attention to numbers thrown out there. Are they peak or trough? Learn the basics of pharmacokinetics so you can inform yourself about TOT World before you go that route. Then at least you can give informed consent before you embark on their large uncontrolled science experiment that they themselves will admit has an uncertain long term result.
BEGIN:
I reached way back for you guys. 1970s-1980s back when we had REAL men.
Donât say I never gave you anything:
https://academic.oup.com/jcem/article-abstract/56/6/1278/2675408
https://academic.oup.com/jcem/article-abstract/37/3/366/2686108
Check out subject III
TEMPORAL VARIATIONS OF TESTOSTERONE LEVELS IN THE PERIPHERAL BLOOD PLASMA OF MEN
Look at subject SFDâŠ
daily variation of the max TT levelsâŠ
Now letâs go back to this plot:
Where do you think these numbers come from? They represent values measured in a sample of men that canât be higher than their peak intraday value . So either itâs the max TT or < max TT level these guys are hitting in a day. Thereâs is almost no one walking the face of the earth âunassistedâ with peak ( much less mean ) daily TT levels above 1200 ng/dl.
After you let that sink in then come back to this:
Be careful to clarify where the â1000â is in the context of treatment. Trough or peak?
Corrected for testosterone amount in the ester, of course you can . A human doesnât eliminate free endogenous testosterone any different than they would eliminate free exogenously introduced testosterone.
Ask yourself, what is being referred to here? Danny gets 1000 ng/dl where on 250 mg/week of test ester? Peak/trough?
The answer would be trough. What would Dannyâs peak TT and mean TT be if he is getting a trough of 1000 ng/dl? Assume E7D or E3.5D injection.
Wtf is TOT?
Yeah thatâs crazy to me.
I think lab ranges are typically 2 standard deviations on each side of the mean, so if we take the typical 9-25ng/dL Free T range, that gives us a mean of 17ng/dL and SD of 4ng/dL.
Free T at 33ng/dL would be 4 standard deviations above the mean. Very high but not completely insane at around 1 in 1000 men with those levels.
Free T at 80ng/dL however would be almost 16 standard deviations above the mean.
Personally I donât really care about the semantics of TRT vs TOT vs cruising vs blasting, etcâŠpeople can define their own priorities. But at some point you have to use common sense, and if youâre hoping to get away with cruising where 1 in 10000âŠ(58 zeros) men theoretically have their Free T, youâre probably in for a bad surprise
âIâll take 8 to 16 Sigma Testosterone Therapy for the win, Bob.â 
#8-16STT4THEWIN
Make sure to check what it is you will be winning though.
Thanks for your thoughts @disciplined_trt. Great points.
Haha.
I was thinking about how Iâd try to explain to someone how absurd 16 SDâs is. And you canât really because those numbers are ridiculous, but I think Iâd go withâŠ
âOk, letâs say we have 10 billion people on the planet. Now imagine thereâs 10 billion times those 10 billion people. Really think about it; itâs not 10, 100 or even 1000 times those 10 billion people, itâs 10 billion times those 10 billion people. Right? OkâŠnow take 10 billion times that population, so that you have 10 billion times 10 billion times those 10 billion people. Now do that again and again and again, so that you end up with a population of 10 billion times 10 billion times 10 billion times 10 billion times 10 billion times the current population of 10 billion people we have. Ok? Now out of that population, there is statistically one guy with Free T at 80ng/dLâ
Again, comparing apples to oranges.
What do you mean? Which comparison doesnât make sense to you?
my emphasis on the [sic]
I think Danny is doing everyday subq, at least currently.
It is interesting though, i dont know if his receptor resistance theory is all bullshit, as i now guys who get no benefit from a low dose for some reason. It would be pretty odd if the same person could feel good on 70mg or 300mg per week.
I kinda like TOT. Itâs more accurate, considering that none of us knows what our healthy Testosterone levels were before we needed exogenous testosterone. So the replacement part of trt, isnât really accurate.
However, we KNOW quite confidently what the the max ceiling was on our endogenous levels in the absence of clinical disease. It isnt a mystery in the slightest. Hence, taking your peak levels (or mean levels) 1.5-2x above the healthy ceiling is absurd in the context of treating legitimate testosterone deficiency.
It is simply bullshit. Check out PAIS. TOT is taking some guys past PAIS levels to treat a presumed testosterone deficiency. I am still waiting for Nichols and Howell to publish that paper on type III hypogonadism due to androgen receptor resistance in the modern man. Canât wait to read it. Must be hard being on the bleeding edge of science.
Thanks for this. In the interest of absolute accuracy i went back and tried to look for Dannyâs injection frequency back when he threw out the dosage and levels i quoted above. Heres is his first post on TNation:
So he was injecting 200 mg/week of TE (twice weekly injections of 100 mg) and he was getting 1200 ng/dl trough. So i will go back and redo the plot that estimates his PK profile. He isnt the outlier he always claims he is in terms of free T elimination. His mean TT is approx 1.2*1182 = 1418 ~ 1400 ng/dl.
Look that up on my graphs aboveâŠhe has approx. 50 percentile response.
All those useless graphs and math @cliteastwood. Unfortunately all that useless info points alot of ignorant suffering people being conned by someone who isnt very good at math, science, physiology, etc.
But he means well you say. Ok. And as we know the road to hell paved with the finest of intentions.
Just spitballing here, what if Danny never tried âcastrate levelsâ, what if there is a sweet spot for pretty much everyone, at 50-70mg per week, when you go past it, you have to go way up to get the ratio right for libido etc, as aromatization does not continue to happen in a linear fashion, at the very least you get more dht when you up the dose, to combat the added estradiol? Could there be something here, i have experienced feeling good with around 100 mgs when its time for the next injection, which then takes that good feeling away, on the other hand i have felt good after injecting a full sustanon, for a couple of days, but itâs different, sleeping is pretty hard and you are kind of hyper.
@tareload dude I am having some serious body heat or hot flashes if thatâs what they are, and get sweaty at night at times. Not sure if itâs the case of diagnosing everything and anything to TRT regimen.
Is it pretty normal for people to have trouble sleeping on gear?
I have always slept like a baby even with larger doses of multiple compounds.
And I have never taken any sleeping aids outside of melatonin.
I have heard from many about the 250mg sustanon injection propionate buzz, making it hard to sleep, it does jack levels quite high for the first couple of days.
Thank you for this hypothesis. I am still thinking about it and we give Danny a lot of thought care here.
Couple of questions for the experienced here. I started on cream a little over 2 weeks ago. Feeling better after a few days which was really nice. My testicles really started to ache though after a week or so and I started to feel like I did before starting trt.
I havenât had blood yet but feel that down feeling I had. Itâs weird but I do feel my blood pressure has increased and my resting heart beat but I cannot afford to go off as I was feeling really depressed without trt. Itâs as if I traded some motivation for anxiety at times though. I know itâs early but I do feel that dialing in is going to be a long haul. Thanks.
Gibbon
