Another item I wanted to check. Here’s a real world provider set from @highpull that we discussed some time ago. I’ve put those data on the graph I shared above to see how they match up.
Since almost all the data he shared are trough TT values (I culled the few non-trough values as per comments in his table.), here’s the key to convert trough values to mean values (AUC mean) assuming 5 day elimination half life:
| mean/trough ratio | |
|---|---|
| q7d | 1.6 |
| q3.5d | 1.21 |
| qod | 1.09 |
| qed | 1.03 |
And drum roll:
Not bad.
Summary for the 200 mg/week group:
- 70% of patients have mean TT level above 1200 ng/dl
- 87% above 1000 ng/dl
- 96% above 800 ng/dl
Summary for the 160 mg/week group:
- 77% of patients have mean TT level above 1200 ng/dl
- 85% above 1000 ng/dl
- 92% above 800 ng/dl
So as you can see leveraging both (1) clinical trial literature data and (2) generous data provided by a TRT practitioner on T-Nation, doses > 150 mg/week Test Ester result in majority of patients having AUC mean TT level above 1200 ng/dl.
Appendix (First column is my calculation of mean TT from trough TT) based on dosing frequency:
| calc AUC mean TT (ng/dl) | WEEKLY DOSE | FREQUENCY | TT (ng/dL) | FTEST (pg/mL) | E2 (IA) | E2 (LC/MS) | SHBG (nmol/L) | fT (ng/dL) |
|---|---|---|---|---|---|---|---|---|
| 1174 | 200mg | q7d | 734 | 193 | 38 | 52 | 21 | 19.3 |
| 1367 | 140mg | q3.5d | 1130 | 310 | 57 | 22 | 31 | |
| 1486 | 120mg | q3.5d | 1228 | 259 | 46 | 24 | 25.9 | |
| 1440 | 200mg | q7d | 900 | 334 | 71 | 7 | 33.4 | |
| 2290 | 200mg | q7d | 1431 | 435 | 35 | 36 | 20 | 43.5 |
| 523 | 160mg | q3.5d | 432 | 89 | 51 | 13 | 8.9 | |
| 1546 | 200mg | q7d | 966 | 241 | 52 | 15 | 24.1 | |
| 1579 | 200mg | q7d | 987 | 134 | 32 | 49 | 13.4 | |
| 1843 | 200mg | q7d | 1152 | 223 | 31 | 32 | 22.3 | |
| 1654 | 200mg | q7d | 1034 | 322 | 22 | 15 | 32.2 | |
| 1475 | 200mg | q7d | 922 | 220 | 56 | 71 | 26 | 22 |
| 1894 | 160mg | q7d | 1184 | 263 | 47 | 28 | 26.3 | |
| 2054 | 160mg | q7d | 1284 | 251 | 36 | 24 | 25.1 | |
| 941 | 140mg | q7d | 588 | 230 | 22 | 9 | 23 | |
| 1715 | 160mg | q7d | 1072 | 184 | 56 | 32 | 18.4 | |
| 1530 | 160mg | q7d | 956 | 197 | 39 | 44 | 19.7 | |
| 1406 | 160mg | q3.5d | 1162 | 196 | 67 | 31 | 19.6 | |
| 1914 | 160mg | q7d | 1196 | 261 | 49 | 25 | 26.1 | |
| 1046 | 160mg | q7d | 654 | 161 | 71 | 17 | 16.1 | |
| 1802 | 200mg | q7d | 1126 | 280 | 36 | 25 | 28 | |
| 1053 | 200mg | q3.5d | 870 | 204 | 15 (AI) | 10 | 17 | 20.4 |
| 1136 | 140mg | q3.5d | 939 | 234 | 76 | 33 | 23.4 | |
| 160mg | q3.5d | 1682 | 589 | 35 | 1 day post | 16 | 58.9 | |
| 1581 | 140mg | q7d | 988 | 163 | 20 | 15 | 16.3 | |
| 1019 | 200mg | q7d | 637 | 146 | 58 | 14 | 14.6 | |
| 1474 | 160mg | q7d | 921 | 276 | 33 | 36 | 26 | 27.6 |
| 2109 | 160mg | q7d | 1318 | 268 | 47 | 40 | 26.8 | |
| 1995 | 200mg | q3.5d | 1649 | 523 | 44 | 10 | 52.3 | |
| 200mg | q7d | 1444 | 408 | 59 | 3 day post | 22 | 40.8 | |
| 1554 | 160mg | q7d | 971 | 211 | 73 | 37 | 21.1 | |
| 891 | 200mg | q3.5d | 736 | 192 | 50 | 38 | 19.2 | |
| 514 | 80mg | q7d | 321 | 58 | <15 | 18 | 5.8 | |
| 832 | 240mg | qod | 763 | 246 | 37 | 12 | 24.6 | |
| 160mg | q3.5d | 2010 | 749 | 40 | 1 day post | 19 | 74.9 | |
| 928 | 160mg | q3.5d | 767 | 169 | 49 | 18 | 16.9 | |
| 1347 | 160mg | q7d | 842 | 167 | 34 | 44 | 16.7 | |
| 909 | 200mg | q7d | 568 | 128 | 46 | 14 | 12.8 | |
| 1366 | 200mg | q3.5d | 1129 | 418 | 24 | 22 | 7 | 41.8 |
| 2592 | 200mg | q7d | 1620 | 440 | 63 | 18 | 44 | |
| 1366 | 200mg | q3.5d | 1129 | 322 | 69 | 29 | 32.2 | |
| 1370 | 200mg | q7d | 856 | 178 | 39 | 44 | 17.8 | |
| 1182 | 200mg | q7d | 739 | 120 | 41 | 36 | 12 | |
| 721 | 200mg | q3.5d | 596 | 126 | 36 | 22 | 12.6 | |
| 160mg | q7d | 2054 | 590 | 41 | 1 day post | 26 | 59 | |
| 150mg | q7d | 1893 | 470 | 45 | 2 day post | 34 | 47 | |
| 1733 | 200mg | q7d | 1083 | 221 | 71 | 24 | 22.1 | |
| 1509 | 180mg | q7d | 943 | 246 | 48 | 30 | 24.6 | |
| 2002 | 200mg | q7d | 1251 | 237 | 53 | 22 | 23.7 | |
| 1618 | 200mg | q7d | 1011 | 267 | 31 | 31 | 26.7 |