I’ve got a question for Cy, or anyone else who can shed some light on this for me. What is the difference between the initial or distributional half-life of a drug and its terminal half-life?
The issue came up because a person was asking whether EOD dosages of Nolva was alright, or if they needed ED dosages. I responded that I thought EOD was fine, as the half-life of Nolva is 5-7 days. Another person then said that Nolva needed to be taken ED, as the initial (or distributional) half-life was only 7-14 hours.
What the hell is the initial or distributional half-life, and how does it figure into proper doseing schedules? This person also said that there are no studies showing the effectiveness of EOD dosages of Nolva.
Thanks for the help,