I can understand SARMS being used in an older population who may be sensitive to the androgenic effects of testosterone, however for a younger male populace will SARM’s be able to cut it? The androgenic profile of testosterone stimulates the development of secondary sexual characteristics, maintainence of adequate libido etc. Will SARM’s be able to fulfill these purposes, think we have a kid with Klinefelters syndrome ( or kallmans or whatever stopped the kid from properly completing puberty) testosterone replacement will help this individual with fat redistribution (particularly in Klinefelters), increased muscle mass, potentially with insulin sensitivity (esp Klinefelters), libido and development of body/facial hair. While choosing a SARM in place of TRT will help in the muscle mass department and potentially in the fat redistribution department (depends on how SARMS affect fat mass and distribution), I don’t see how a SARM can help out with the development of secondary sexual characteristics and increased libido that testosterone gives, am I missing something here? It just seems silly to use something that isn’t testosterone for… Testosterone replacement, if an individual doesn’t like injections, well methyltestosterone and fluoxymesteorne (halotestin) are still approved agents for trt, halo can be prescribed up to 20mg/day and methyltestosterone up to 50mg/day, toxicity be damned, apparently some people would prefer that over a tiny injection, I actually can’t believe these medications are still approved in the USA, there’s a ton of methyltestosterone unused just sitting around, can’t believe it hasn’t made its way onto the BM yet. And at least these two agents are derivitaves of and structurally closely resemble testosterone!
Estrogen is required for optimal bone density, libido and wellbeing among a host of other positive effects, using a SARM in place of TRT will tank natural testosterone levels, possibly leaving estrogen production in the gutter, seriously, how can this be a good idea, I must be confused somehow. There’s absolutely no WAY doctors would prescribe these drugs in place of TRT if it was riskier than TRT