I forgot one of the biggest, zero downside intervention. Fish oil... Biotest has some of the best Omega-3 complexes. Too bad it is outside of my budget.
Dosages though again seem extreme, but not when you realize how much is missing from our food supply.
I'm on 10 grams/day. I go up to 20g day when workouts are intense. It takes a while to work (think week or so) but from a lifting program perspective it is roughly equivalent to Naproxem/Ibu for inflammation and soreness, only it targets only the negative inflammation and works long term. New studies show NSAIDs anti-inflammatory effects are non-specific and the anti-inflammatory effects stop working with chronic use.
The flushing varies widely day over day. You do acclimate to it, so the effect diminishes with persistent usage. Some report dramatic redness. I turn quite pink. Some report the the itchy feeling, others do not. I happen to do both. Funny, it also seems to nearly cure acne. My son is 14, almost 15. 3 days and he'll clear right up. He HATES the flushing though. Then again, that makes sense in a way, as it massively increases blood flow to the skin (vasodialator) and alters blood lipids.
However, an expected side effect of statins are demylination. The stripping of the nerve fibers. A result of that is memory loss, decrease in cognitive function. I think for a living, and learning is a core part of who I am... To a fault even... So these effects are completely unacceptable. This effect is inherent in the mechanism of action, some do it more, some less.
The studies are all over the map with statins in people with out immediate acute cardiac issues. Almost all show improvement in blood lipid profile, though some show increase in mortality. Few show decline in mortality. I think it is the confusion of a marker of risk with actual outcomes... There are no long term studies that I'm aware of. Long term, I mean relative to the current recommended usage of being on them for decades.
I also think that most Dr.s see people who will not make lifestyle changes. They get inured to people who would not cross the road to save themselves, but they will pop a pill every day.
Me, I'll go near Dean Ornish, if I have to, to avoid statins.