In case you don't know that already, although his team is still called The Sports Palace, Jim Schmitz's place is now (until he opens a new Sports Palace):
387 Grand Ave.
South San Francisco, CA 94080
Diablo Barbell is in the East Bay, so if you're staying in SF, avoid the rush hour at all cost. Unless you want to experience crossing the Bay Bridge in rush hour on purpose, for the "experience".
My recommendation would be to leave the car at the hotel and visit San Francisco on foot and / or using the Transit system. You can start on Union Square and take the cable car, stop by Chinatown and then hop back and go to Fisherman's Wharf.
You can catch the Ferry to Alcatraz over there.
After that (or some other day, if you spend a lot of time in Alcatraz -- days are still pretty short!) you can then rent a bike and go west, by the Bay, visiting Fort Mason, the Marina, the Palace of Fine Arts, the Presidio and then go across the Golden Gate bridge. It's a heck of a workout, and it's the best way to experience the beauty of SF, especially if you catch a sunny day.
You might also be interested (maybe in another day) to visit the Coit Tower and Lombard Street, but I don't know if that's your kind of sightseeing.
Stay away from other areas -- namely the Western Addition and Bayview / Hunter's point, at night in particular. Nothing to see there, and although it's not exactly a dangerous city (far from it), I want you to see the best San Francisco has to offer, not the worst...