I was just curious as to this subject. I don’t plan to do orals in my first cycle (starting soon just waiting on the gear to arrive) but in the future I may look into it. I’ve taken a few pharmacology courses in the past and, while looking through an old textbook to find something, I stumbled on the specifics of rectal administration.
Now my curiosity lies as to whether this may apply to steroids as well. Knowing that, when administrated rectally, there are less vessels leading to the liver and more leading to direct systemic circulation post-administration, and therefore avoidance of the “first pass effect” for most of a drug is possible, thereby saving your liver from more damage then necessary. As this is possible with a lot of orally administrated drugs (since oral technically means from the GI tract to the anus), is it also a possibility with oral steroids?
I look forward to hearing your answers. I did a search on the internet but I could not find any answers. If this is the case, I think everyone will be a little more educated about this subject, if they find it convenient to do so. I know this is the route I’ll take in the future if it’s fully possible.