I’m kind of exhausted from that issue. Since 2017 I’ve been on gear, competing. I’ve tried many different approaches, and the problem persists - my sweet spot for E2 seems to be very narrow, and I haven’t found anyone to have the same experience so far all these years. It’s really painful to live like that, I have to perform blood tests at least once weekly.
To start with, I’m an experienced and educated AAS user. No matter if using testosterone solo, or if in a stack with other androgens/E2-generating compounds, orals or injectables - the range I feel comfortable with is always 30-38 pg/mL (there are periods I check that in a lab even 2x/week!). To keep that in this range I base it on anastrozole’s (my only AI) half-lives dosing that daily with a 0,05 mg precision. It works well for a matter of 1, sometimes 2 weeks, but then I have to adjust that based on experienced side effects and lab results, for example increasing/decreasing the dose by 0,1 mg/daily.
Currently, I’m on a testosterone cypionate cycle (600 mg/wk, e3d dosing, along with 250 IU of hCG e3d as well), and there’s a need to use 0,15-0,25 mg of anastrozole daily, to keep E2 in the abovementioned range. All other hormones all in check, including thyroid hormones, progesterone, DHEA, prolactin, and so on. The same while using antidepressants (there were periods they were necessary).
Side effects I experience when below the range are almost the same as those associated with when above. The only difference is more exacerbated anxiety when too low and loss of appetite, and more nervousness when too high (no that anxiety then and appetite is often increased). Sexual function is reduced significantly in both states, but I experience it more when E2 is lowered. Fog mind and sleepiness, depressive thoughts are the same, and so on (joint pain, back pain, short-term memory, confidence level). However, those differences are rather subtle, I can’t predict if a state I’m in is caused by lowered or increased E2 - I always need to check that with lab results to decide how to dose my AI.
I’ve tried to use pharma-grade testosterone enanthate, as well as Omnadren - results when it comes to E2 were the same, but costs were significantly greater, obviously.
Do you know someone having the same trouble? Any ideas on how to solve that? Multiple guys who I coach are functioning very well when their E2 is way above the range, I wish I could too. The issue limits all my areas of life, not to say sometimes ruins it…