I wanted to post this study for anyone dealing with varicocele and going on TRT. For a long time I’ve pondered if my symptoms were from low sex hormones or adrenals/thyroid being out of “whack”. When I initially started getting symptoms directly after getting a varicocele due to injury, they mimicked that of post-finasteride usage, or someone who had been castrated (literally). My labs were coming back in the normal range just my libido disappeared and my testicle atrophied. Around this time I started having weird ED/shrinkage and weight gain around my mid section. Energy/mood wise I had some changes, but nothing major. I’ve always been somewhat “lean”, so it wasn’t overly noticeable. Mood was “okay”.
Because the left testicle is connected to the left adrenal/kidney, it made sense to me that the adrenal gland hormones may also get “messed up” with a varicocele forming, not just impacting the testicle itself. This article explains this does happen and the reasons why:
Essentially, the adrenals over-produce anti-steroid hormones like progesterone (which is always elevated in varicocele sufferers), cortisol, etc and various other hormones that disrupt the actual sex hormones and lead to issues with libido/ED, etc.
I’ve been on TRT for roughly 8 weeks and have seen little improvement, and this seems to be the case for a lot of varicocele sufferers. I don’t have a definitive answer on how to resolve this situation, because it’s pretty complex - one may be taking cortisol in low dosages to suppress adrenal hormone production, though I am still researching this further and don’t have an exact answer.
I am interested to hear from other guys on TRT who have/had varicocele and managed to get improvements from treatment.