T Nation

Using HCG by FORGENIRON


#1

It is our opinion that HCG is probably one of the most misunderstood and misused compounds in bodybuilding. Hopefully this information will go some way towards rectifying that for the members of MuscleTalk. HCG stands for Human Chorionic Gonadotrophin and is not a steroid, but a natural peptide hormone which develops in the placenta of pregnant women during pregnancy to controls the mother's hormones. (Incidentally, this is the reason you may hear of people testing for growth hormone (HGH) with a pregnancy testing kit - If their HGH shows 'pregnant', they've been ripped-off with cheaper HCG - but we digress slightly).

Its action in the male body is like that of LH, stimulating the Leydig cells in the testes to produce testosterone even in the absence of endogenous LH. HCG is therefore used during longer or heavier steroid cycles to maintain testicular size and condition, or to bring atrophied (shrunken) testicles back up to their original condition in preparation for post-cycle Clomid therapy. This process is necessary because atrophied testicles produce reduced levels of natural testosterone, this situation should be rectified prior to post-cycle Clomid therapy.

HCG administration post-cycle is common practice among bodybuilders in the belief that it will aid the natural testosterone recovery, but this theory is unfounded and also counterproductive. The rapid rise in both testosterone, and thus oestrogen due to aromatisation, from the administration of HCG causes further inhibition of the HPTA (Hypothalamic/Pituitary/Testicular Axis - feedback loop discussed above); this actually worsens the recovery situation. HCG does not restore the natural testosterone production.

The typically observed dosing of 2000 to 5000IU every 4 to 5 days causes such an increase in oestrogen levels via aromatisation of the natural testosterone that this has been responsible for many cases of gynecomastia.

From the above discussion it is clear that HCG is best used during a cycle, either to:

1) Avoid testicular atrophy, or
2) Rectify the problem of an existing testicular atrophy.

Doses of HCG
Smaller doses, more frequently during a cycle will give best overall results with least unwanted side effects. Somewhere between 500iu and 1000iu per day would be best over about a two-week period. These doses are sufficient to avoid/rectify testicular atrophy without increasing oestrogen levels too dramatically and risking gynecomastia. This dosing schedule also avoids the risk of permanently down-regulating the LH receptors in the testes.

Presentation and Administration of HCG
Synthetic HCG is often known as Pregnyl (generic name) and is available in 2500iu and 5000iu (not ideal for the above doses!). Administration of the compound is either by intra-muscular or subcutaneous injection. It comes as a powder which needs to be mixed with the sterile water. The powder is temperature-sensitive prior to mixing and should not be exposed to direct heat. After mixing, it should be kept refrigerated and used within a few weeks - though there are sterility issues which need to be considered after mixing.

Summary and Price of Clomid and HCG
Clomid is more effective than HCG post cycle, but some long-term users like to use HCG during a cycle, or to prepare the testes for Clomid therapy.


Doses of HCG
Smaller doses, more frequently during a cycle will give best overall results with least unwanted side effects. Somewhere between 500iu and 1000iu per day would be best over about a two-week period. These doses are sufficient to avoid/rectify testicular atrophy without increasing oestrogen levels too dramatically and risking gynecomastia. This dosing schedule also avoids the risk of permanently down-regulating the LH receptors in the testes.


directions
Add the water to powder with the water given bro. After combining you need to refrigerate and it is good for about a month.

A 10,000iu kit comes with 1cc (or ml.) of sterile water. Once you reconstitute, 10ius on an insulin point equals 1000ius and done 10iu points (slin pin).
If no vial to put in pre-load slin pins and refrigerate.

Reconstitute is when you combine water and powder in one.

The the powder will just dissolve when the water is mixed via syringe instantly..it should be the active powder.

10ius on an insulin point equals 1000ius in typical HCG kit.....

The IU units are on the pin and its translates in terms of slin iu points as follows for typical 10,000iu kit:

a 10,000 iu kit if taken 5iu a day for 20 days=10,000..

Thats how I dose a 10,000 iu kit 20 days, you will find it works very well spread out ED for 20 days.

I personally get 29ga slin pins 1/3 cc per pin and fill 4 slin pins to 25 iu points,assuming you have 1 ml of water like most kits, and must be kept cold after mixing in fridge or freezer maybe in a box to conceal

10ius on an insulin point equals 1000ius.....(on slin pin).
5ius on slin pin=500iu of 10,000iu kit.
thats assuming you used the 1 ml of bac water it came with.
confusing hugh

I would like to know how true this is and if so then Why do so many people recommend it?


#2

I don't understand the part about useing it as an ancillary during a longer cycle at 500-1000 iu every day "over a 2 week period of time". What does this mean do you cycle off of hcg after 2 weeks? if so then what? Guys I know who are useing it as an ancillary during a cycle to keep d'boys from atrophying are useing it only 1 or 2 days a week. How do we know the 500-1000 iu a day is not enought to desensitise lydig cells? Is there any empirical data showing this?


#3

I don't know exactly, that is why I posted this to get more information about it. That is a very good question though. I will see what I can find and get back to you. Anybody else who wants to help though please do so, HCG has me confused on whether or not to use it all and just stick to clomid therapy with Nolva.


#4

I agree from experience and friends' experience that 500-1000IU 1-2days per week, only while on gear, is the way to go. This is to keep the testes from shrinking. The idea is if the testes stop production of T for a bit that's bad, now if they atrophy that is worse. So it's to prevent the atrophy then use other means of pct when coming off. I'm a nolv fan myself.
While on use as little HCG as possible to keep the boys big. So if 500IU 1x/week does it, then stay with that.