Could there be any potential issues with trt and hepatosplenomegaly? Could exogenous testosterone (issued at doctor prescribed levels) potentially cause more inflammation and enlargement of the spleen and liver? I am asking out of curiosity as I haven’t been able to find any information on this online. I have been prescribed trt (haven’t decided to start) and have unexplained hepatosplenomegaly. The doctor did not seem concerned but I haven’t been able to find anything online to come to my own conclusion.
as I have a response to this but it involves me finding and linking certain pieces of literature that I’ve read before, it’s very late here thus I’m drained… I’ll edit this tomorrow. (and I mean it, many times I forget… but this is very important)
Ultimately it probably depends on you’re overall dosage. Like most tissues in the body, the liver contains androgen receptors. All hormones have to pass through the liver once (or twice with c17AA anabolics)… However testosterone, being recognised by the body as a naturally occurring hormones is particularly open to metabolism via the liver. Particularly strong, structurally modified, synthetic derivitave such as trenolone can exhibit hepatotoxicity despite not being not having that extra methyl/ethyl group at the 17th carbon position of the steroid backbone. This being said it still appears increased testosterone levels increase the risk for development of hepatocellular carcinoma
Not to say I think testosterone alone elicts a directly hepatotoxic action, but testosterone inhibition (at least within rodents) appears to increase apidonectin, a protein that can stunt/slow tumour growth.
Thank you for the information, it definitely puts my mind at ease and makes me more comfortable with the idea of trt for life.
I’ve been dealing with so many doctors over the past 2 years trying to figure out what’s causing my symptoms that I have lost faith in their reliability. I’ve had 3 internal medicine doctors and 2 endocrinologists tell me I’m fine when I had low t and anemia. Never hurts to double check what the doctor says, they aren’t always the fountain of all knowledge.
If it did, this would be the first I’ve heard… which, for me, is an indication that it most likely doesn’t. Otherwise this would be coming up at times in our FB group with the number of topics that get brought up on a daily basis.