TRT + SSRI (Viibryd) = Increased E2?

You have the facts right but do not know the impact.
Vilazodone - Wikipedia
Vilazodone - Wikipedia

Not a very friendly drug.

Impact: Have you ever been on a SSRI before? It rewires your brain and when you stop taking it it can be a tough number of days. Might be better from a sexual function point of view, but Wellbutrin is too without any of the classic negative effects of SSRI’s.

Can we see current labs?
Do you have thyroid labs?

Please eval overall thyroid status via oral body temps - see below.
Thyroid does have a big impact on mood and energy when non-optimal.

Have you looked at other things like nutrients and supplements that might have an impact on your general wellbeing?


Please read the stickies found here: About the T Replacement Category - #2 by KSman

  • advice for new guys - need more info about you
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc

Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.

KSman is simply a regular member on this site. Nothing more other than highly active.

I can be a bit abrupt in my replies and recommendations. I have a lot of ground to cover as this forum has become much more active in the last two years. I can’t follow threads that go deep over time. You need to respond to all of my points and requests as soon as possible before you fall off of my radar. The worse problems are guys who ignore issues re Thyroid, body temperatures, history of iodized salt. Please do not piss people off saying that lab results are normal, we need lab numbers and ranges.

The value that you get out of this process and forum depends on your effort and performance. The bulk of your learning is reading/studying the suggested stickies.