Danazol: I cannot see that is decreases SHBG but is can occupy SHBG so there is less FT lost to SHBG+T. We have guys feeling great without Danazol and perhaps you might too.
I suggest that T dose be increased to get to top of range and anastrozole increased to get near E2=80pmol/L. Both will tend to reduce SHBG.
fT3 near 5.0 should support good oral body temperatures and energy and mood. When fT3 is ~midrange and body temperatures are low we suspect that elevated rT3, reverse T3, is blocking fT3. fT3 is the only active hormone; there is no receptor for T4. See the thyroid sticky for references to rT3 and stress issues that can lead to elevated rT3.
Blood seems a bit thin for TRT and PCV, packed cell volume aka hematocrit HTC is low. MCV is elevated. This suggests possible low level GI bleed, blood loss. Do you have any gut or digestive issues. You can ask for test that detects low levels of blood in your poop. Ferritin lab work would also have some bearing. Serum iron results are often not useful as this can be dominated by recent meals.
Please read the stickies found here: About the T Replacement Category - #2 by KSman
- advice for new guys - need more info about you
- things that damage your hormones
- protocol for injections
- finding a TRT doc
Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.
KSman is simply a regular member on this site. Nothing more other than highly active.
I can be a bit abrupt in my replies and recommendations. I have a lot of ground to cover as this forum has become much more active in the last two years. I can’t follow threads that go deep over time. You need to respond to all of my points and requests as soon as possible before you fall off of my radar. The worse problems are guys who ignore issues re thyroid, body temperatures, history of iodized salt. Please do not piss people off saying that lab results are normal, we need lab number and ranges.
The value that you get out of this process and forum depends on your effort and performance. The bulk of your learning is reading/studying the suggested stickies.