T Nation

TRT and Pain Meds - Liver Function Affected. What About T Levels?


#1

Due to recent back injury, I’m now taking Ultram ER for pain relief

Hopefully this will only be very short term (like a couple weeks)

Out of curiosity, does taking opioid meds like this with TRT cause extra stress on the liver or kidneys?

And I’ve read opioid use reduces T levels, but does that apply to someone on TRT as well?

Thanks


#2

My guess would be that opioids affect natural T production. Since your T is exogenous your levels should be unaffected. I don’t know that this is the case, but that’d be my guess.


#3

Any medication that is metabolized by the liver is going to cause some stress, which might increase some enzymes. Shbg might go up a little too from the meds, but I wouldn’t be worried about it as long as you are doing it short term and not abusing or mixing with alcohol.


#4

Opioids basically sedates your entire body’s central nervous system to remove the pain, it has negative consequences on other systems as well.


#5

HI systemlord,

So far I’ve been finding the opposite - the ultram is providing a boost in energy (until it wears off anyway) as well as the pain relief

I don’t know why it provides the energy boost but its also detrimental, it’s keeping me out of sleep, if I take it within 6 hours of going to bed I will wake up 3 or 4 times through the night and each time I wake up it takes about 40 minutes to fall asleep again

I might need to talk to my Dr to try something else, the Ultram doesn’t sedate me which is good for during the day but it keeps me awake at night