Hello, I’ve currently been on TRT for 2 years, no issues, also no health issues, 30, eat and train well.
I’ve recently discovered I have the homozygous TT mutation for MTHFR T677T.
This gene is involved in the methylation cycle.
This basically means I don’t process folate properly and homocysteine levels can build up which can lead to increase cardiovascular disease, I’ve ordered a homocysteine test to check my levels.
From what I’ve read there also seems to be an increased risk in thrombosis with this phenotype but is that just due to the elevated levels of homocysteine? Does this risk decrease once you correct homocysteine levels?
I know TRT itself can increase the risk of thrombosis too.
I’m wondering if anyone here has this gene mutation too? Or if anyone who knows about it and TRT could spread shed some light on it for me please?
Is TRT still safe with this mutation?