T Nation

TRT and Epigenetics

Epigenetics is defined as: the study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself.

Gene expression can be changed through things like diet and exercise, as well as by environmental factors, and it can be passed on to future generations. Dr. Rhonda Patrick explains in the following clip how sperm collected from both obese men and lean men differed along the hundreds of genes tested by researchers. The obese men had their sperm tested before and after bariatric surgery and their resulting weight loss. It was found that the gene expression of their sperm looked more like that of the lean men after obese men lost weight.

As for us on TRT, would it then stand to reason that our genes would be altered through our hormone optimization and passed on to the next generation? Does anyone have studies on this at all?