Treating Depression

Did not read the entire thread but this has helped me with my seasonal depression in the winter months.

From most to least significant;
-2,000 IU of Vitamin D
-Tanning at least twice a week
-3 Fish Oils
-Training consistently
-Changing my study lamp light to resemble day time
-Using melatonin to sleep
-Socializing more
-Taking a break from work and my studies (winter holidays)
-I have a “happy” light coming that I can wear when I wake up to get my days going.

[quote]Goodfellow wrote:
So getting right to the point:

I feel like shit, I have no ‘vitality’ and I go to sleep of a night hoping I don’t wake up the next morning. I know have plenty to live for, I’m in good health, smart, relatively good looking I guess, but I just can’t shake this feeling of emptiness I’ve had for the last 6 months or so.

Does anyone have any advice for getting over this sort of thing? I feel that it would be a bit of a dramatic step to go see a psychiatrist.

P.S. I still go to the gym, 12 times a week lately, mostly because I can shut my brain off and not think about anything.
[/quote]
Ah, time to put my learnin’ to use!
Okay, depression isn’t that complicated. That’s the good news. Getting over it is a pain in the ass, that’s the bad news.
Situational depression would be a case where an event or series of events, negative stressors, has caused you to have the blues. If this is the case then that is something that can be treated with cognitive or behavior modification therapies. These therapies basically are positive coping mechanisms that allow you to alter your paradigm and adjust your point of view. What I mean by point of view is basically a way to count your blessings. For instance, a concentration camp victim isn’t going to be all affronted over a break up with a girl, where a young healthy man, who has had a relatively cushy life will be devastated. These therapies can help, but they are limited. The brain is an organ and it can get sick, either by nature or nurture.

Depression can be genetic, where there is no good reason to feel ‘blue’, you know it, but you do anyway.
However, this ‘clinical’ state can be hit by an major trauma, several traumas, or a series of never ending events. Just like if you drink heavily everyday, your liver will get sick, a litany of negative stressors can cause your brain to get sick, it gets stuck. You hit any organ with enough stress, that organ will get sick. So any depression can become clinical if the stressors in your life are unrelenting. Or you just may have a genetic predisposition to singing the blues.

You haven’t given a whole lot of info for the basis of your depression, but it’s one of the two or a combination of both. Only you can account for what the cause is, it’s worth your while to check your family history. There is still a stigma attached to mild mental issues, but if you have a genetic component that is in play, if family won’t admit, you can tell by their behavior. The behaviour to look for is compensation. Sometimes negative, like excessive drinking of drug abuse is a self medication. Obsessive behaviours such as being a work-a-holic, engaging in hobbies and putting an unhealthy importance on their importance, anger, sleep issues (too much or too little), etc. are all signs of compensation.

You really do want to account for at least trying to determine a partial cause as it will help you better understand why you are feeling the way you do.

Now, what to do about it…
One thing to do, is to get away. Go on a long vacation, go to somewhere where nothing is the same as what you do normally. Go have some fun. When you come back, you can better understand your environment, if your environment is putting undo stress on you, you may be able to recognize it better when you haven’t been in it for a while. That’s the perspective thing. A lot of times, things are so common place, you don’t even recognize them as problematic until you haven’t been in that situation for a while.

Check your friends. Are they bringing you down? It’s possible for people to appear to be your friend, but be bringing you down. The key way to recognize a negative relationship is to evaluate how selfish a person is. Selfish people will destroy if they can, with a smile on their face. While suiting their own purposes, they may be giving you “help” that is actually destroying you. The thing about narcissistic people is that often they don’t know it, but the more selfish a person is, the worse they are for you. Selfishness destroys in inexpressible ways. Everybody is selfish to a point, but there is a line. When everything is about them, they are bad people who need to go.

Now for the good stuff, drugs…

Now the common thought surrounding depression is serotonin. When the brains ability to absorb or use serotonin is compromised, then feelings of depression are sure to follow. Dopamine has also been found to be lesser player, but a player nonetheless in depression. Here’s where it gets a bit more complicated, because it’s not levels of serotonin that’s the problem, it’s absorption.
The most common and effective medications are called SSRI’s or selective serotonin reuptake inhibitors. What these drugs do, with a variety of side effects, is prevent the synaptic reuptake of unused serotonin, leaving more serotonin out to be ‘plugged’ into the receptors. Does it work? Yes, quite effectively however, there is still more to the story.
The issues of synapses is another key in the equation. Why is there serotonin to reuptake in the first place? It could be one of two things, the creation of synaptic branches has been compromised by the stress on the brain or again, you genetically don’t have a good process for it. Or your synapses are compromised and don’t absorb said neurotransmitters well.
Where this occurs in your brain will also effect the kind of depression you have. For instance, if this is happening in your amygdala primarily, you will have a lot of anxiety associated with your depression.
Sex hormones play a pivotal role in synapse function and generation. For instance, if you are suffering from low testosterone, or a woman low estrogen, depression can ensue. Depending on your circumstance, hormone treatment may be a more effective treatment for depression than the SSRI’s. The problem is most Dr’s won’t look at that side of the equation, but low sex hormone production is highly correlated with depression. In other words, get your sex hormone levels tested. Don’t accept ‘normal’ as an answer either, it has to be normal for your age. If your pumping 300 nl/dl of testosterone, that will be ‘normal’ according to charts, but normal ranges from 200 nl/ dl to 1200 nl/dl. Two people who have completely different levels, one six times higher than the other, can both be considered normal. A normal mid 20’s male should be pumping between 600 - 800 nl/dl. You should not be hitting 300’s until your like 50.
If you are pumping decent sex hormone levels, then you have something else going on and probably need the SSRI’s.

The problem with drug treatments is that they are seldom a temporary fix. It does happen that people can take them for a while, taper off and be fine. But often it necessitates a life time commitment. So there is a lot to think about when it comes to treating this.

i think i’d like to go back on antidepressants again just for the sexual side effects. i had alot of fun with long, hyper, desperate sex. it is like having a cork in your wang that you need to build up pressure to cum out. it is something everybody should try once

i believe there are people who just simply have low serotonin. they have many traits in their personality aside from having a low mood.
my twin sister grew up in the same enviroment with me and has worse genes than i, but she is jovial and blissfuly ignorant of what depression feels like.

the confidence one could get on paxil could help them make permanent changes in their life for the better

Thanks for that post pat, loads of good stuff to think about there. I’ll definitely think twice about getting my hormone levels tested now.

Daily ice cold showers helped me.

[quote]Legionary wrote:
Daily ice cold showers helped me.[/quote]

This isn’t the porn addiction blog.

[quote]conservativedog wrote:

[quote]Legionary wrote:
Daily ice cold showers helped me.[/quote]

This isn’t the porn addiction blog.

[/quote]

“Exposure to cold is known to activate the sympathetic nervous system and increase the blood level of beta-endorphin and noradrenaline and to increase synaptic release of noradrenaline in the brain as well. Additionally, due to the high density of cold receptors in the skin, a cold shower is expected to send an overwhelming amount of electrical impulses from peripheral nerve endings to the brain, which could result in an anti-depressive effect.”

[quote]Legionary wrote:

[quote]conservativedog wrote:

[quote]Legionary wrote:
Daily ice cold showers helped me.[/quote]

This isn’t the porn addiction blog.

http://tnation.T-Nation.com/free_online_forum/music_movies_girls_life/porn_addiction
[/quote]

“Exposure to cold is known to activate the sympathetic nervous system and increase the blood level of beta-endorphin and noradrenaline and to increase synaptic release of noradrenaline in the brain as well. Additionally, due to the high density of cold receptors in the skin, a cold shower is expected to send an overwhelming amount of electrical impulses from peripheral nerve endings to the brain, which could result in an anti-depressive effect.”[/quote]

I also hear that it helps with test production… Or just generally living a more robust lifestyle instead of a sedentary seems to lead to way higher test scores as well… Probally all that testosterone is having no reason to be used when you are sitting around all day like a docile cow.

[quote]Goodfellow wrote:
Thanks for that post pat, loads of good stuff to think about there. I’ll definitely think twice about getting my hormone levels tested now. [/quote]

Your welcome. I am going to try to send you a PM. They haven’t worked in quite a while, but if there is anything you want to discuss outside public view, I would be happy to help were I can. Let me know if you get it… It’s only a test.

that sounds like weird advice to tell a person with depression that they have low testosterone. that would be like if i went on corn-nation.com and posted that i had depression they would say that it sounded like i needed to eat more corn.
also, if goodfellow is young,has huge biceps and has low T then what does that mean for me? i must be lucky to be alive because i am sure i dont have as much testosterone as he.

[quote]eremesu wrote:
that sounds like weird advice to tell a person with depression that they have low testosterone. that would be like if i went on corn-nation.com and posted that i had depression they would say that it sounded like i needed to eat more corn.
also, if goodfellow is young,has huge biceps and has low T then what does that mean for me? i must be lucky to be alive because i am sure i dont have as much testosterone as he.
[/quote]

Wasn’t even flexing in that pic either :wink:

Has anyone had any success with opioids for depression?

I’ve been through a gamut of SSRIs and SNRIs, with nothing doing much for me. The only thing that had any effect was Viibryd, and it just made me suicidal. (But at least it did something.)

I took some Tramadol last night for some neck pain, and for the first time in months, I actually felt “good” again. Not “high”, just “normal”. I reconfirmed that again today.

Chemically, Tramadol is similar to Effexor, which didn’t work for me… but I’m just wondering if there might be something to this.

Anyone else have similar experiences?

I’m working my way through a thread talking about Tramadol and depression… and I understand there’s significant abuse and addiction potential, so it’s not like I’m saying this is a good idea. Just wondering if anyone else has experienced the same.

[quote]LoRez wrote:
Has anyone had any success with opioids for depression?

I’ve been through a gamut of SSRIs and SNRIs, with nothing doing much for me. The only thing that had any effect was Viibryd, and it just made me suicidal. (But at least it did something.)

I took some Tramadol last night for some neck pain, and for the first time in months, I actually felt “good” again. Not “high”, just “normal”. I reconfirmed that again today.

Chemically, Tramadol is similar to Effexor, which didn’t work for me… but I’m just wondering if there might be something to this.

Anyone else have similar experiences?

I’m working my way through a thread talking about Tramadol and depression… and I understand there’s significant abuse and addiction potential, so it’s not like I’m saying this is a good idea. Just wondering if anyone else has experienced the same.[/quote]
Tramadol is not an opiate its a central opioid agonist and is not even close to Effexor which is a SNRI.
Are you sure it was Tramadol?

[quote]Derek542 wrote:

[quote]LoRez wrote:
Has anyone had any success with opioids for depression?

I’ve been through a gamut of SSRIs and SNRIs, with nothing doing much for me. The only thing that had any effect was Viibryd, and it just made me suicidal. (But at least it did something.)

I took some Tramadol last night for some neck pain, and for the first time in months, I actually felt “good” again. Not “high”, just “normal”. I reconfirmed that again today.

Chemically, Tramadol is similar to Effexor, which didn’t work for me… but I’m just wondering if there might be something to this.

Anyone else have similar experiences?

I’m working my way through a thread talking about Tramadol and depression… and I understand there’s significant abuse and addiction potential, so it’s not like I’m saying this is a good idea. Just wondering if anyone else has experienced the same.[/quote]
Tramadol is not an opiate its a central opioid agonist and is not even close to Effexor which is a SNRI.
Are you sure it was Tramadol? [/quote]

Yes, I’m sure it’s Tramadol. As far as it being an opioid, I guess it’s not technically an opioid… just that it has opioid effects, inclusive of the addictive properties.

And:
http://journals.lww.com/smajournalonline/Abstract/2008/02000/Similar_Effects_of_Tramadol_and_Venlafaxine_in.25.aspx

“The analgesic tramadol has many characteristics in common with the antidepressant venlafaxine. The drugs are structurally similar, share both serotonergic and noradrenergic properties, and undergo a similar metabolic fate.”

[quote]eremesu wrote:
that sounds like weird advice to tell a person with depression that they have low testosterone. that would be like if i went on corn-nation.com and posted that i had depression they would say that it sounded like i needed to eat more corn.
also, if goodfellow is young,has huge biceps and has low T then what does that mean for me? i must be lucky to be alive because i am sure i dont have as much testosterone as he.
[/quote]

Testosterone is far from the only component needed for muscular hypertrophy, and feel free to cross reference anything I have said. I didn’t say he has low T, I said it’s a possibility. You can have high T and be clinically depressed. There are many possible reasons for depression. The best thing to do is root cause analysis. Hormonal imbalance can most definitely be a reason. The effect of the sex hormones on the brain, particularly the health and regeneration of synapses is not something to over look. It’s to often overlooked actually.

Further, aren’t you the one who wanted to take Paxil to last longer in the sack? Drink whiskey, it’s faster and less caustic than Paxil.

[quote]LoRez wrote:

[quote]Derek542 wrote:

[quote]LoRez wrote:
Has anyone had any success with opioids for depression?

I’ve been through a gamut of SSRIs and SNRIs, with nothing doing much for me. The only thing that had any effect was Viibryd, and it just made me suicidal. (But at least it did something.)

I took some Tramadol last night for some neck pain, and for the first time in months, I actually felt “good” again. Not “high”, just “normal”. I reconfirmed that again today.

Chemically, Tramadol is similar to Effexor, which didn’t work for me… but I’m just wondering if there might be something to this.

Anyone else have similar experiences?

I’m working my way through a thread talking about Tramadol and depression… and I understand there’s significant abuse and addiction potential, so it’s not like I’m saying this is a good idea. Just wondering if anyone else has experienced the same.[/quote]
Tramadol is not an opiate its a central opioid agonist and is not even close to Effexor which is a SNRI.
Are you sure it was Tramadol? [/quote]

Yes, I’m sure it’s Tramadol. As far as it being an opioid, I guess it’s not technically an opioid… just that it has opioid effects, inclusive of the addictive properties.

And:
http://journals.lww.com/smajournalonline/Abstract/2008/02000/Similar_Effects_of_Tramadol_and_Venlafaxine_in.25.aspx

“The analgesic tramadol has many characteristics in common with the antidepressant venlafaxine. The drugs are structurally similar, share both serotonergic and noradrenergic properties, and undergo a similar metabolic fate.”[/quote]

It sucks as a pain killer.

[quote]pat wrote:

[quote]LoRez wrote:

[quote]Derek542 wrote:

[quote]LoRez wrote:
Has anyone had any success with opioids for depression?

I’ve been through a gamut of SSRIs and SNRIs, with nothing doing much for me. The only thing that had any effect was Viibryd, and it just made me suicidal. (But at least it did something.)

I took some Tramadol last night for some neck pain, and for the first time in months, I actually felt “good” again. Not “high”, just “normal”. I reconfirmed that again today.

Chemically, Tramadol is similar to Effexor, which didn’t work for me… but I’m just wondering if there might be something to this.

Anyone else have similar experiences?

I’m working my way through a thread talking about Tramadol and depression… and I understand there’s significant abuse and addiction potential, so it’s not like I’m saying this is a good idea. Just wondering if anyone else has experienced the same.[/quote]
Tramadol is not an opiate its a central opioid agonist and is not even close to Effexor which is a SNRI.
Are you sure it was Tramadol? [/quote]

Yes, I’m sure it’s Tramadol. As far as it being an opioid, I guess it’s not technically an opioid… just that it has opioid effects, inclusive of the addictive properties.

And:
http://journals.lww.com/smajournalonline/Abstract/2008/02000/Similar_Effects_of_Tramadol_and_Venlafaxine_in.25.aspx

“The analgesic tramadol has many characteristics in common with the antidepressant venlafaxine. The drugs are structurally similar, share both serotonergic and noradrenergic properties, and undergo a similar metabolic fate.”[/quote]

It sucks as a pain killer.[/quote]

Pretty much unrelated, but some tricyclics and SSRI’s are being used to treat certain types of pain.

[quote]Fletch1986 wrote:

[quote]pat wrote:

[quote]LoRez wrote:

[quote]Derek542 wrote:

[quote]LoRez wrote:
Has anyone had any success with opioids for depression?

I’ve been through a gamut of SSRIs and SNRIs, with nothing doing much for me. The only thing that had any effect was Viibryd, and it just made me suicidal. (But at least it did something.)

I took some Tramadol last night for some neck pain, and for the first time in months, I actually felt “good” again. Not “high”, just “normal”. I reconfirmed that again today.

Chemically, Tramadol is similar to Effexor, which didn’t work for me… but I’m just wondering if there might be something to this.

Anyone else have similar experiences?

I’m working my way through a thread talking about Tramadol and depression… and I understand there’s significant abuse and addiction potential, so it’s not like I’m saying this is a good idea. Just wondering if anyone else has experienced the same.[/quote]
Tramadol is not an opiate its a central opioid agonist and is not even close to Effexor which is a SNRI.
Are you sure it was Tramadol? [/quote]

Yes, I’m sure it’s Tramadol. As far as it being an opioid, I guess it’s not technically an opioid… just that it has opioid effects, inclusive of the addictive properties.

And:
http://journals.lww.com/smajournalonline/Abstract/2008/02000/Similar_Effects_of_Tramadol_and_Venlafaxine_in.25.aspx

“The analgesic tramadol has many characteristics in common with the antidepressant venlafaxine. The drugs are structurally similar, share both serotonergic and noradrenergic properties, and undergo a similar metabolic fate.”[/quote]

It sucks as a pain killer.[/quote]

Pretty much unrelated, but some tricyclics and SSRI’s are being used to treat certain types of pain. [/quote]

It does suck as a pain killer, but it’s great for my mood.

[quote]LoRez wrote:
Has anyone had any success with opioids for depression?

I’ve been through a gamut of SSRIs and SNRIs, with nothing doing much for me. The only thing that had any effect was Viibryd, and it just made me suicidal. (But at least it did something.)

I took some Tramadol last night for some neck pain, and for the first time in months, I actually felt “good” again. Not “high”, just “normal”. I reconfirmed that again today.

Chemically, Tramadol is similar to Effexor, which didn’t work for me… but I’m just wondering if there might be something to this.

Anyone else have similar experiences?

I’m working my way through a thread talking about Tramadol and depression… and I understand there’s significant abuse and addiction potential, so it’s not like I’m saying this is a good idea. Just wondering if anyone else has experienced the same.[/quote]

Tramadol is quite popular on other board I frequent.

Everyday use - forget it. Especially if you’re after an anti-depressant effect. Your tolerance will build fairly quick and it’s that point you’ll either need to hop off the ride…or start messing with higher doses, which is never a smart thing with opiod acting drugs.

Couple of times a week, you can get away with that, but there are probably better long-term strategies.

Have you tried any of the older tricyclics or the MAOI’s?. These tend to be far better drugs really than the SSRI’s but docs are relucutant because their overodse margin is quite low and they carry a fair few interactions respectively.

I’ve had good success with the unique SSRE Tianeptine which I started last year.

Best of luck.

[quote]CopingMechanism wrote:

[quote]LoRez wrote:
Has anyone had any success with opioids for depression?

I’ve been through a gamut of SSRIs and SNRIs, with nothing doing much for me. The only thing that had any effect was Viibryd, and it just made me suicidal. (But at least it did something.)

I took some Tramadol last night for some neck pain, and for the first time in months, I actually felt “good” again. Not “high”, just “normal”. I reconfirmed that again today.

Chemically, Tramadol is similar to Effexor, which didn’t work for me… but I’m just wondering if there might be something to this.

Anyone else have similar experiences?

I’m working my way through a thread talking about Tramadol and depression… and I understand there’s significant abuse and addiction potential, so it’s not like I’m saying this is a good idea. Just wondering if anyone else has experienced the same.[/quote]

Tramadol is quite popular on other board I frequent.

Everyday use - forget it. Especially if you’re after an anti-depressant effect. Your tolerance will build fairly quick and it’s that point you’ll either need to hop off the ride…or start messing with higher doses, which is never a smart thing with opiod acting drugs.

Couple of times a week, you can get away with that, but there are probably better long-term strategies.

Have you tried any of the older tricyclics or the MAOI’s?. These tend to be far better drugs really than the SSRI’s but docs are relucutant because their overodse margin is quite low and they carry a fair few interactions respectively.

I’ve had good success with the unique SSRE Tianeptine which I started last year.

Best of luck.
[/quote]

The tricyclics often have more side effects too.