If you only train once a week you need to raise the intensity, since frequency is low.
I have decent experience in this matter, since I am having problems going to the gym more than twice weekly.
My own investigations on how to maximize output led to HIT/Dr Darden. It worked for me, but I guess i depends on whether you believe in or even like this form of training. People/trainees who advocate higher volume training seldom have anything positive to say about HIT. For all I hear, Wendler’s system seems to be the solution to everything gym related (I am not saying it isn’t so - have yet to try it).
But, in answer to you question I recommend Dr Dardens fullbody 30-10-30 program once a week. Just search the T-nation articles and you will find a description on how to do it (and yes, the article is a small study on new, young trainees who made some fantastic progress - as all young trainees do no matter what type of training). That being said, 30-10-30 will challenge your thoughts about training and probably give a good result, provided you have not trained like this before.