T Nation

Toxins in Fat Cells


So I was browsing the internets and came across these two things which sparked my interest

and later:

Something else I read was that as your body fasts it goes into a detoxification mode, and so sometimes when fasting toxins in fat can be released into the blood stream and filtered out etc.

I am wondering whether these pieces of information are fact or fiction and how scientifically sound they are. No one really talks about this. I wonder because my friend said that he is cautious of loosing heaps of weight really fast because all the toxins built up over his years of drug use will make him sick as it all dumps from the fat cells into the bloodstream.

Are there ways to detox yourself of fat-soluble toxins without actually loosing fat? etc etc

If anyone has information on it then I would be glad to read it.



It's true. no further info at my fingertips though


Could this be why the first pulse fast is causing such nasty headaches? I tried 2 caps of Ibuprofen the day of the fast, and it couldn't cure this headache.



Some people just don't respond well to a drastic change in dietary intake, especially carbs. If you're glycogen is low and you're exercising it can be quite easy to drop in a strongly ketogenic state from a 24 hour fast with protein. A LOT of people get a keto headache which will, if you continue to stay ketogenic, go away generally after a day to 3 days.

Myself, I get the headache the first day I go into ketosis, then will be sluggish for a couple of days then if I maintain ketosis I'll be fine from then on. The body has to adapt.

So ... I'd say your headache could probably be a keto headache. Google can help if you want more info on that.


Consume activated charcoal. It may help. WRT to the toxins. I dont know much about ketogenic diets


I remember reading an abstract where Orlistat (the fat loss supplement that inhibited pancreatic lipase, thus made you hershey squirt all day) was used with success to achieve a lower level of fat-soluble body toxins (organochlorines).

Here it be: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T8P-4N1CRSW-4&_user=10&_coverDate=03%2F31%2F2007&_rdoc=5&_fmt=summary&_orig=browse&_srch=doc-info%28%23toc%235092%232007%23999819996%23644013%23FLA%23display%23Volume%29&_cdi=5092&_sort=d&_docanchor=&view=c&_ct=12&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=dfd4a3a749f0553465d1d38beaae041f

Essentially, the fat soluble toxins would just be taken into your gut and then back into your body when you digest said fatty acids; if you poop the fatty acids out there is a chance that they will chelate said toxins out with them.

So short of Orlistat, there is a chance that a high fat diet with a lot of insoluble fiber to form a complex with said dietary fats could act in the same manner.

I would imagine that fasting would have no effect on fat-soluble toxin excretion; what is their vehicle to leave the body unless you poop out fat? Merely burning the fat for fuel would not provide any transport out of the body.


The liver break them down and you would the rest down with your urin, which is why you should a lot when fasting.


That is assuming the fat-solubles can be broken down. I have heard reports that some toxins are present in fat cells currently which have been omitted from all manufacturing processes for decades. It would lead me to believe the body would rather just redeposit it in fat cells than break it down, or if the enzymes needed to break some down are not present in humans.

This probably is different for every toxin though, as I have heard of some fat-solubles being cleansed by the liver.


Generally speaking, compounds which are fat soluble but which have extremely low water solubility are, first, slowly excreted because very little at any one time is in free solution in the blood; and second, are far more readily removed from the body if they can be metabolized by the liver to more water-soluble compounds so that they may excreted in the urine.

Where a compound is fat soluble, has extremely low water solubility, and is resistant to being metabolized to a more water solubility, then rate of removal from the body can be extremely slow.


Chlorella is supposed to be an excellent chelator of heavy metals and binder of certain toxins.


If in a fat loss phase (effectively releasing fat soluble toxins), fat soluble toxins (like PCBs, BPA, etc) would be released (into the blood) much more rapidly, right? What would your opinion be on taking chlorella to bind PCBs and DIM/flax-lignan or some other estrogen binding supplement to block the toxin/artificial estrogen from reabsorbing? Maybe also a liver suport like milk thistle?


Post did not show up before. Anyway...

Bill/Others: If in a fat loss phase, thoughts on taking the following:

Bind to the released toxins: Chlorella (effective on PCBs and other toxins)
Block reabsorption of xenoestrogens: resveratrol and extra flax (lignans)

Worthy experimental approach? Any modifications or additions?

I'm thinking about doing this on pulse-fast days (twice a week during a month long fat loss phase). I might also throw in some cilantro in there to induce release of mercury, to which chlorella will bind.


Chlorella can't do anything, I believe, with regard to anything in the bloodstream, as what is absorbed from digestion of chlorella won't retain the properties in question.

If a significant degree of enterohepatic circulation exists with the toxin in question then having chlorella fairly consistently in the GI tract might aid elimination. (By this I mean, if the toxin tends to partially transfer into the GI tract and then get reabsorbed, it could block the reabsorption.)

If the toxin were harmful to the liver it might be the case that milk thistle would help that.


Maybe it is because you are not eating? That often causes headaches at first.


There is no substantial increase in released toxins unless there is a substantial percentage decrease in the amount of bodyfat, which doesn't happen in one day. So that cannot be the cause. Big Banana may well have hit on it exactly.


I've read eating acidic foods can help with the elimination of toxins.


Thanks for the responses. I will plan accordingly.


I was just thinking of that ex prime minister of ukraine who had massive dioxin poisoning. He probably shouldn't start a fast...


This is very interesting..
I did my first Pulse Fast yesterday and when I came home to shower I noticed skin rash on my upper body.. especially my chest and upper abdomen. I imagine it is due to toxins being released of some sort. Today, it seems to be slowly getting better.
Anybody else experience this?


Yeah I hadn't much thought about it previous to this thread, but it makes complete sense that increasing fat loss beyond what the body is accustomed to (eating at maintenance calories vs. exercising while in calorie deficit, especially in ketosis, and IMO ESPECIALLY on Pulse Fast (TM) days) would increase the toxin load on your system to a level that you are not accustomed to handling. You're rash could be entirely not related though.