In response to Bill Roberts first post in this thread, Dr. Walsh also said in the Article Discussion:
"Firstly let me share my utmost respect for Bill Roberts. I've followed his work for probably about 10 years now and appreciate his knowledge, ability to convey complex information and willingness to share it with others. He's an asset to the bodybuilding and weightlifting world.
I'm not an expert in pharmacology. I'm a clinician who spends the bulk of my time with patients. Any free time I have is generally dedicated to researching and learning ways of helping patients get better, faster, but with all the information available, it's never quite enough.
As for transdermal PS, compounding pharmacists have the technology available to them to get many different compounds through the skin. Botanicals, vitamins, hormones - they can all be applied on the skin and supposedly get into the bloodstream. Again, this isn't my area of expertise, so I leave it to people that know more than I.
What I can tell you is that I've seen a faster, more dramatic lowering of cortisol, as per adrenal salivary testing, when I started using transdermal PS than when I used oral. There is approximately 600mg of PS per 1/2 tsp of product. I've never seen studies on how much gets through, but I'd love to. I was very untrusting of it myself until I started using it on patients and seeing results.
Oral is fine for mg dosages. But when you start to get into the gram range, there can be negative side effects, and it's a little pricey. Until published research is available, my 'research' is in the clinic and what I see working best for patients."