Carlito: Does TargeX work or not?(Same for your rival Yohimburn?) Do you have to be at a low bodyfat before using/seeing results?(pecs/abs/obliques)…[/quote]
Thanks for asking,
TargeX does work and thisproduct was formulated based on this study:
Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application.
Armanini D, Nacamulli D, Francini-Pesenti F, Battagin G, Ragazzi E, Fiore C.
Department of Medical and Surgical Sciences-Endocrinology, University of Padua, Via Ospedale 105, 35100 Padua, Italy.
Cortisol is involved in the distribution and deposition of fat, and its action is regulated by the activity of 11beta-hydroxysteroid dehydrogenase. Glycyrrhetinic acid, the active principle of licorice root, blocks 11beta-hydroxysteroid dehydrogenase type 1, thus reducing the availability of cortisol at the level of adipocytes. We evaluated the effect of topical application of a cream containing glycyrrhetinic acid in the thickness of fat at the level of the thigh. Eighteen healthy women (age range 20-33 years) with normal BMI were randomly allocated to treatment, at the level of the dominant thigh, with a cream containing 2.5% glycyrrhetinic acid (n=9) or with a placebo cream containing the excipients alone (n=9). Before and after 1 month of treatment both the circumference and the thickness of the superficial fat layer of the thighs (by ultrasound analysis) were measured. The circumference and the thickness of the superficial fat layer were significantly reduced in comparison to the controlateral untreated thigh and to control subjects treated with the placebo cream. No changes were observed in blood pressure, plasma renin activity, plasma aldosterone or cortisol. The effect of glycyrrhetinic acid on the thickness of subcutaneous fat was likely related to a block of 11beta-hydroxysteroid dehydrogenase type 1 at the level of fat cells; therefore, glycyrrhetinic acid could be effectively used in the reduction of unwanted local fat accumulation.
If you read the original abstract you will note that …
“No changes were observed in blood pressure, plasma renin activity, plasma aldosterone or cortisol”,
There was no change in plasma cortisol; cortisol was lowered only in the fat cells, this is telling us that little if any of the compound was absorbed systemically or we would see a drop in whole body, i.e. plasma cortisol.
To answer your second question, NO TargeX is not like Yohimburn at all, YB ingredients are HCL YB, ALCAR, Histidine and others…well these are good in aiding the body to burn/mobilize fat but in my opnion these are out together in a TDS instead of a capsule, simple as that! I personally do not think YB has a localized fat burning effect and if there is any is more likely water loss due to its ingredients, not trying to take credit off this productas I know of good feedback and coming from someone ( me ) who used it before i feel safe to say what I said above.
TargeX targets subcutaneous fat by blocking cortisol’s fat accumulatiing properties and more.