T Nation

Thyroid/T3- PCT

I found this interesting. I usally start a Thyroid PCT 10 days before discontinuing use of T3. Done 3 cycles and never had a problem, PS this info came from someone a lot smarter than me:

Thyroid Post Cycle Therapy.

Here is a list of supplements and recommendations I have compiled for your thyroid post cycle therapy.


Several nutrients are critical for the proper functioning of the thyroid gland. In order for the thyroid gland to produce the hormone thyroxine, it needs the trace elements iodine and selenium, and the amino acid Tyrosine. Without sufficient supply of the nutrients in the diet, thyroid function is diminished. A typical regimn of dietary supplements I recommend in support of thyroid function are listed below.

BLADDERWRACK (fucus vesiculosus)

Bladderwrack, or fucus, consists of the marine plant fucus vesiculosus. Marine algae have been used in Europe and Asia as medicinal agents for thousands of years. Bladderwrack is a rich source of iodine and is traditionally used for weight loss and hypothyroidism. Bladderwrack is thought to stimulate the thyroid gland, thus increasing basal metabolism. Bladderwrack also contains potassium, magnesium, calcium, iron, zinc, and other minerals.

RECOMMENDED DOSE. 300-600 mgs, standardized to contain not more than 150mcg of iodine daily, one to three times a day.

COLEUS (coleus forskolii)

Coleus has been extensively researched in India over the last twenty years as a medicinal agent useful for thyroid support and for conditions such as high blood pressure, asthma, and weight loss, among others.

Coleus is also thought to activate the enzyme adenylate cyclase. In doing so, it increases the level of cyclic adenosine monophosphate (cAMP) within cells ( cAMP, as you may recall, is important in the activation of several biochemical pathways). This catalyst is formed when neurotransmitters bind to the cell membrane and stimulate the formation of adenylate cyclase. Specific hormonal messengers bind to receptor cites to create the release of cAMP. Therefore, while Coleus is involved in hormonal regulation, it doesn’t increase hormone levels. Instead it helps improve the effeciency of binding to target receptor cites. The stimulation of cAMP has an impact on the body chemistry in several ways. It stimulates thyroid function, increases insulin secretion, inhibits histamine release (involved in allergic reactions), and increases the burning of fats as fuels. Coleus is claimed to inhibit platelet activating factor (PAF)–that si, the formation of blood clots–by possibly directly binding to PAF receptor cites.

RECOMMENDED DOSE. 250mgs of a 1 percent extract of coleus, twice a day. CAUTION: people with ulcers or who are taking blood pressure medication and anticoagulant medications should check with your healthcare professional before taking Coleus.

CORDYCEPS (cordyceps sinesis)

Cordyceps Is important for people with improperly functioning thyroid glands because people with low thyroid function have reduced oxygen utilization and increased oxidative stress. Cordyceps acts as an antioxidant, improves oxygen utilization by 15%, improves stamina, and reduces fatigue–all critical issues for people with poor thyroid regulation.

RECOMMENDED DOSE. 525mgs of cordyceps, standardized to contain .14 to .18 percent adenosine and 5 percent mannitol, two to three times a day.


Low thyroid function leads to poor conversion and utilization of essential fatty acids (EFA’s). Without quality sources of dietary fat, particularily the Omega-3 fatty acid alpha-linoleic acid (ALA) and the Omeaga-6 fatty acid gamma-linolenic acid (GLA), the body is unable to regulate hormonal influence over certain cells. EFA’s are the building blocks of eicosanoids, a group of “super hormones” that act as hormonal gatekeepers of the cells. EFA defficiencies and overproduction of inflammatory prostaglandins are associated with a variety of illnesses, including slowed metabolism and increased storage of body fat.

RECOMMENDED DOSE. The best sources of GLA are borage and evening primrose oils. Sources of Omega-3 fatty acids are cold water fish ( salmon, mackerel, tuna trout, haddock), flaxseeds and flax oil. Although both EFA’s are essential to our health, the ratio of omega-3 to Omega-6 oils in our diet should be 1:3. Udo’s oil contains 3,6, and 9 fatty acids.

GUGGUL (commiphora mukul)

Guggul has been described in Indian medical literature as an agent for treating obesity and other eating disorders. Guggul was marketed as a lipid lowering agent in 1980, Guggul has been reported to stimulate thyroid function, which may lead to blood lipid lowering and weight loss, as well as improved thyroid function in hypothyroidism.

RECOMMENDED DOSE. 500mgs, three times a day, standardized to contain 5 percent gugglesterones. CAUTION: people taking prescription medications for cardiovascular disease such as calcium channel blockers or beta blockers, as well as those with hyperthyroidism, should check with there physician before taking Guggul.


If you can’t get your hands on the bladderwrack, then sources of iodine include sea vegatables (nori, hijiki, wakame, kombu, and kelp), sea salt, and all seafood and saltwater fish. Iodized salt is another source, but contains to much aluminum, Iodized sea salt, however supplies iodine without unwanted aluminum.

RECOMMENDED DOSE. 225-1000mcg of iodine daily


Without sufficient available tyrosine, the adrenal glands have a sluggish or inadequate response to stress: heart rate, blood pressure, airway, and metabolism are diminished. And when the tyrosine pool is drained to make stress hormones, there is less available to make adequate levels of thyroid hormones. Tyrosine supplements have been used as nutritional or adjunctive support for the treatment of depression, anxiety, sleep disorders, and weight gain, all of which are associated with hypothyroidism.

RECOMMENDED DOSE. 250-750mg of L-Tyrosine daily. Most body builders and athletes eat plenty of amino acids throughout the day, so supplementing with tyrosine isn’t as important unless your under significant stress your body temp is low, and you have other symptoms of low thyroid effeciency.


Thyroid glandular is a bovine-derived thyroid substance that may boost the human thyroid system when the gland is not functioning optimally. Glandular supplements are carefully processed animal gland tissue; thyroid glandulars contain extremely low levels of thyroid hormone. It is theorized that glandular tissues contain proteins that help the thyroid gland to rebuild itself. This has been very effective with people who have subclinical hypothyroid function…it has also been used in place of thyroid meds with great success.

RECOMMENDED DOSE. T-100X…Is a good source of not only thyroid glandular, but also contains: Thyroid glandular ( thyroxine free) 100mg…Adrenal gladular 50mg…pituitary glandular 15mg…spleen glandular 5mg…thymus glandular 5mg…and It also contains bladderwrack 15mg…along with a few supportive herbs. Made by “Advanced Orthomolecular Research” (AOR) check out their website for more info. So as you can see T-100X is good for more than just thyroid support, it’s quite effective at stimulating your total immune system…this baby is a must!!!

DOSE. 1 tab (630mg) twice a day for post cycle or if you already have a low Resting Temp.


Chromium depletion may influence thyroid function. Chromium is a necessary mineral for the conversion of carbohydrates to energy, and helps maintain a stable blood sugar level. It is also an essential component to enzyme function that supports the conversion of T4 to T3. So chromium can indirectly impact your basal metabolic rate and how you are going to burn fat, use nutrients, and generate energy. Selenium has also been linked to subclinical hypothyroid symptoms. Selenium is found in selenoproteins, many of which have known roles in the prevention of cellular oxidative damage and thyroid hormone regulation. Selenium is an essential component of the enzyme iodothyronine deiodinase, the enzyme that converts thyroxine (T4) to the active triiodothyronine (T3). As with Zinc, selenium supplementation has been reported to improve thyroid function and regulate symptoms of hypothyroidism. Other nutrients important for optimum thyroid function include zinc and copper. These trace minerals are also required for the synthesis of iodothyronine deioinase.

Studies have concluded that that zinc supplementation can restore normal thyroid function among people with low serum zinc, and signs of subclinical hypothyroidism. Zinc is required for the activity of more than 200 different enzymes in the body. Supplementing with extra zinc requires the addition of copper to maintain healthy zinc to copper ratio. Since the two elements antagonize one another, supplementing with one can kead to a deficciency of the other.

RECOMMENDED DOSE 200mcg of chromium daily as part of a multivitamin/mineral supplement; 200mcg of selenium daily; anf 15 parts zinc to 1 part copper, or approx 20-50 mg of zinc to 2 mg of copper.


Many physician now recognize the problems with thyroid regulation. In fact, the window for acceptable TSH levels has just recently been changed by the American Society of Endocrinologists so that millions more people may get diagnosed with hypothyroidism and get the help they need. Hopefully the use of t3 and t4 as drug therapy will become more popular, and in addition, the various influencers of thyroid metabolism such as stress and nutrient abnormalities will begin to become more recognized in the coming decade. Healthy thyroid function is crucial to graceful and vital aging. So whether you try Armour thyroid, nutritional approaches, get compounded thyroid therapy, or use traditional drugs, keep one thing in mind: If there’s no relief of low-thyroid symptoms, you are probably still missing a piece of the metabolic puzzle.


With all that said you can pick from the list provided above to determine your needs, or what’s available to you…this is what I do with great success, I mean my temp is usually bang on every morning, the only time my temp drops or raises, is when I want it too!

Coleus forskolii (acti-cyclase) 250mg twice daily when taking T3, 3 times daily when i’m not.

T-100X. 630mg twice daily for post cycle (As mentioned above this is the glandular form) This ones a must!!!

Life extension mix (powder) This baby is pricey but contains everything you need to sustain life. But for thyroid purposes : 200mcg selenium: 200mcg chromium: 75mcg iodine: 35mg zinc: 2mg copper

Udo’s oil contains omega 3,6, and 9 fatty acids…I use 2 tablespoons in my protein drinks, 2 tablespoons per can of tuna in place of mayo. I cook with it, you can even poor it on popcorn in place of butter…I say this because my GF is a popcorn freak.

Backing off on training is a plus when doing long thyroid cycles. If your training 5 days a week, then try 4 days a week for the first 2 weeks when coming off t3, remember your adrenals will rob you of tyrosine to make cortisol. And since training and rest are 2 big factors of stress, lets give your body the extra edge for regulating your thyroid function with as little hinderance as possible. Try to make sure you get adequate rest when coming of thyroids also, this will help with the return of normal thyroid function as well.

1 Like

thx for that post!
really intresting!
im wondering if you would like to give more details about your t3 cycle, results, dosage, lenght…

I wish I could remember the article I read where it was shown that thyroid levels returned to baseline after three weeks of cessation from T3 intake up to 100mcg. daily for several weeks on end.

This was shown to have occurred for the whole panel of people who participated in the study. If I can ever find it again I’ll certainly post it.