Most people that use any form of anabolic steroids are aware of the negative feedback loop for testosterone, where the body shuts down natural test on account of the hormones (steroids) you have been putting in your body. Well what if I said they may be a way around this. Any aas even oxandrolone a mild anabolic adrogenic steroid to some degree shuts down natural test.
It has been shown that as little as 2.5 mg a day has an effect on the hpta. What if I said that its not the steroids responsible the shut down but a signal from the brain or the over production of gaba from the gaba a receptor in the brain. It has been shown that gaba has a negative effect on testosterone or more precisely the firing of Gonadotropin-Releasing Hormone Neurons. As this study demonstrates:- http://endo.endojournals.org/cgi/content/abstract/endo;145/2/495
For those that are not aware what gaba is its substance that is abundant in the brain responsible the calming effect on the brain or inhibiting over stimulation of the brain alcohol is a gaba a agonist (stimulator) its well known that alcohol lower test levels. Also steroids stimulate gaba production of the gaba a receptor this study on stanozolol (winstrol) shows that.
OK so far we have established that the gaba a receptor is responsible for the chemical interaction in the body to signal your body to stop producing LH the precursor to test when on cycle through the steroids having a stimulatory effect on gaba a receptors in the brain. Are you still with me? OK
So far we have concentrated on the gaba a receptor now I want to concentrate on the gaba b receptor which has the opposite effect on test. The study that follows was done on animals but is interesting it showed that a gaba b agonist or stimulator completely reversed the negative feedback loop of testosterone after testosterone administration.
Still with me ok the drug they used in this study was baclofen which is not freely available to the average bodybuilder. But you might be interested to know that baclofen in a derivative of phenibut a russian supplement used for anxiety which is freely available on any supplement site and is even sold on ebay.
Just to summarise phenibut use while on cycle could prove a very useful supplement. As the study shows a gaba b agonist which phenibut is, reverses the negative feedback loop of test. More research is needed but reversing the negative feedback loop would be very advantageous for those on cycle. inhibition of natural test is the biggest problem with using gear.
Post cycle recovery would be minimal as the body would still be producing lh and therefore test. I would think that an anti estrogen may be needed on cycle though with the abundance of test in the system. But a gaba b agonisty may be something to consider.