What do you guys feel the goal is of HRT? Is it consistently higher stable T-levels, or more fluctuating T-levels, with spikes although higher average than natural. I ask this because I'm curious what the most effective HRT therapy is, injection, oral, cream?
My understanding is injection causes a large spike in T levels immediately after the injection, and then fall as the week goes on until the next injection. This would seem to have some negative side-effects on natural testosterone production as well as conversion to estrogen and PSA levels. I'd expect this would also cause some mood swings. The upside is potentially great muscle growth in the immediate days following the injection as well as gauranteed delivery/uptake.
The alternative is something daily (or I guess you can split an injection to a daily dosage, but that would be alot of injecting). Assuming a decent absorbion, the idea would seem to elevate the T levels and then keep them there with little variation during the week. A doctor indicated that if taken during the morning, the half life is typically around 12 hours so natural T production can kick in at night. Of course, that may need to be revved up a bit if you already have some low T levels, but it would seem the more stable approach. The apparent downside to gel/creams/pills is having to take something every day, as well as never having supra-normal T levels. Creams/gels would be prefered instead of pills to avoid liver toxicity.