"Competitive inhibition of delta-6-desaturase. Referring to the diagram below, you'll notice that the first step is dependent on delta-6-desaturase. When you take significantly more omega-3 than omega-6 â?? or vice versa â?? they compete against one another. This is why I tell people that super-loading omega-3 is not a good idea.
If you take in too much omega-3, you'll have issues converting omega-6, which is also essential. So don't fall for the "take 20-30 grams of fish oil a day" recommendations.
Fact is, some topnotch doctors report seeing patients with unusual bleeding and joint pain from taking excess omega-3. On the other hand, problems also occur with ingesting too much omega-6, which happens to be much more biologically active and will set the stage for more inflammation.". (from managing inflammatio).
Then there's there's many coaches who recommend exactly this or even more, You hear Poliquin talking about freakish muscle gains by mega dosing his athletes with it, Just curious to hear opinions, experiences etc.