Hi guys, I’m new here, pharmacy student with some thoughts on AAS pharmacology to share with you.
Test:
- provides E2 and it’s anabolic effects
- reduction of SHBG (high affinity to the protein), CBG, TBG
- 11BHSD2 & 11-hydroxylase inhibition (excessive water retention even w/o E2)
- androgenic properties
Test is what I call a good compromise when we consider a bulking phase.
Nandrolone:
- slight E2 & estrone synthesis
- reduction of SHBG (however, has low affinity to the protein)
- increase of TBG
- partial agonist/antagonist to PR (slight increase of ER synthesis so elevated E2-related sides)
- doesn’t affect 11BHSD2 but probably inhibits 21-hydroxylase (decreased synthesis of corticosteroids) - if E2 in check, shouldn’t provide any significant water retention
- low androgenocity (DHN, more estrone, E2 from test and unfavorable androgenic/estrogenic ratio)
It seems that PR&ER-related sides from nandrolone comes only in an excess of E2 coming from testosterone aromatization (some amounts of estrone comes from nandrolone as well - E2 reservoir). Almost a perfect steroid with strong anabolic properties w/o much androgenocity and E2-related sides. Positive impact on joints probably comes from early peak of cortisol after a therapy is started, the effect disappear over chronic use.
Drostanolone:
- doesn’t convert to E2 obviously
- very potent affinity to SHBG (decreases this protein in a strong manner as well), lowers CBG and TBG
- no influence on MR and GR (no water retention) and it’s ligands related enzymes
- good androgen (better than on the paper)
- probably an aromatase inhibitor (no evidence for direct ER-antagonism)
- anabolic properties comes from AR stimulation and reduction of SHBG
Used instead of another ancillary drugs, in addition the drug delivers training aggression and strength which makes the process of hypertrophy phase a bit easier (and is very mild in an aspect of side effects). It helps to move retained water from wet compounds from SC space to muscle tissue.
The thing is to choose your dosages accordingly, more is not always better (remember about AR-desensitization and dimishing returns from massive AAS intake). Trenbolone would be a great addition to the cycle if you accept another sides from the compound.