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Test Undecanoate 40mg Caps, Long Term Usage

I want to dedicate this thread to anyone that has been on the above long term…
And any information that anyone thinks is worth contributing to Testoreone Undecanoate 40mg caps.

I have been taking test orally for over 13 months now and have felt great but as of yet know nothing of the long term affects… Most the studies I have read so far have been for less than a year… Im still researching.

Is there anyone else out there that has been on undecanoate 40mg caps long term?
If so I would appreciate your input.

So far I have found it to be absolutely brilliant, giving me lots of energy and no issues.
Not shrunken family jewles either…
I’ll keep you guys up to date with how I feel on it.
I admit to worrying a little about the affects of having the repeated spikes and troughs while taking it but so far all good.

Again please feel free to contribute if you think you may have any info on this topic worth a mention…


Just something I have googled on it… Some I understand, some I don’t!

“14.3.1.5 Testosterone undecanoate
When testosterone is esterified in the 17Ã?-position with a long fatty acid side
chain such as undecanoic acid and given orally, its route of absorption from the
gastrointestinal tract is slightly shifted from the vena portae to the lymph and
CaDomwnbloraiddedg fero mB Coamobkrisdg eO Bnoolkins Oen ©bCy aIPm 16b5.2r2id8.g15e9. 2U24n oniv Weerds Mitayr P0 0r0e:5s7:s13, B2S0T 0209
412 H.M. Behre et al.
Fig. 14.2 Single-dose pharmacokinetics of testosterone undecanoate after oral administration of
120mg of the ester to 8 hypogonadal patients. Because of high interindividual variability of
testosterone serum concentrations after administration of testosterone undecanoate, individual
curves were all centralized about the time of maximal serum concentrations (time
0). Asterisks indicate significantly higher testosterone serum concentrations compared to
pretreatment values (basal) (mean ± SEM).
reaches the circulation via the thoracic duct (Coert et al. 1975; Horst et al. 1976;
Shackleford et al. 2003). Absorption is improved if the ester is taken in arachis oil
(Nieschlag et al. 1975) and with a meal (Frey et al. 1979; Bagchus et al. 2003). After
oral ingestion of a 40 mgcapsule, ofwhich 63% i.e. 25 mgis testosterone, maximum
serumlevels are reached two to six hours later (Nieschlag et al. 1975). Thus,with 2 to
4 capsules (80 to 160 mg) per day substitution of hypogonadism can be achieved.
Testosterone undecanoate pharmacokinetics after single-dose administration
were tested in eight hypogonadal patients and twelve normal men (Sch¨urmeyer
et al. 1983). Directly before and at hourly intervals after oral application of three
times 40 mg of testosterone undecanoate in arachis oil taken together with a standardized
breakfast, matched saliva samples, as a parameter for free testosterone at
the tissue level, and blood samples were collected hourly for up to 8 h. After administration
of testosterone undecanoate, serum and saliva testosterone always showed
a parallel rise and fall, as demonstrated by a constant saliva/serum testosterone
ratio. On average maximum levels could be observed five hours after testosterone
undecanoate administration.However, the serum testosterone profile showed high
interindividual variabilityof the timewhenmaximumconcentrationswere reached,
aswell as of the maximumlevels themselves that ranged from17 to 96 nmol/l.When
the individual serum concentration versus time curves were centralized about the
time of maximal serum concentrations, serum concentrations significantly different
from basal values were seen only two hours before and one hour after the time
of maximal serum concentrations in hypogonadal patients (Fig. 14.2) (Sch¨urmeyer
CaDomwnbloraiddedg fero mB Coamobkrisdg eO Bnoolkins Oen ©bCy aIPm 16b5.2r2id8.g15e9. 2U24n oniv Weerds Mitayr P0 0r0e:5s7:s13, B2S0T 0209
413 Pharmacology of testosterone preparations
et al. 1983). Based on this observation it can be deduced that even with administration
of testosterone undecanoate 3 times daily, only short-lived testosterone peaks
resulting in high fluctuations can be obtained.
This judgment is in agreement with the data of a two-month multiple-dose
study with testosterone undecanoate for replacement therapy in hypogonadal men
(Skakkebaek et al. 1981). Applying a double blind cross-over design, serum testosterone
levels were studied in 12 hypogonadal patients to whom 80 mg of testosterone
undecanoate had been administered twice per day 12 hours apart.Whereas
four hours after administration of testosterone undecanoate a significant increase
of testosterone serum levels was observed compared to the placebo group, twelve
hours after administration no significant difference in testosterone serum levels
between treatment and placebo control group was seen. Even four hours after
administration, in four of twelve patients testosterone levels were still below the
lower level of the normal range after both one month and two months of treatment.
Asignificant marked variability between subjects aswell aswithin the same subjects
has also been observed in other clinical studies (Cantrill et al. 1984; Conway et al.
1988).
The original preparation of oral testosterone undecanoate had to be refrigerated
(2â??8â?¦C) in the pharmacy for reasons of stability, whereas patients must store it at
roomtemperature to ensure optimal absorption. The shelf-life at roomtemperature
is only three months. Therefore, a new,more stable pharmaceutical formulation of
testosteroneundecanoatewas developed inwhich the oleic acid solventwas replaced
by castor oil and propylene glycol laurate. This new formulation can be stored at
room temperature (15â??30â?¦C) for three years (Bagchus et al. 2003). According to an
unpublished randomized multicenter study in 49 hypogonadal men, oral administration
of 2 Ã? 80 mg or 3 Ã? 80 mg of the reformulated testosterone undecanoate
might result in more physiological and stable serum testosterone levels.”

This looks good.

"
A new oral testosterone undecanoate formulation.

Abstract

Testosterone undecanoate has been available on the market for more than 20 years. This testosterone ester is used worldwide for oral treatment of male hypogonadism. So far, testosterone undecanoate has been dissolved in oleic acid, leading to inconvenient storage conditions. It will now be available in a new formulation with castor oil and propylene glycol laurate instead of oleic acid, thus improving storage conditions markedly (stable at room temperature for approximately 3 years). Pharmacokinetic and pharmacodynamic studies have demonstrated bioequivalence of the old and the new formulation of testosterone undecanoate. Therefore, the results of studies that were performed with the old formulation can be transferred to the clinical use of the new formulation. Controlled studies have shown its efficacy in the treatment of symptoms associated with reduced serum testosterone levels. In these cases testosterone undecanoate improves bone mineral density, quality of life, muscle mass, libido and mood. Further studies will help evaluate the efficacy and safety of the new formulation in the treatment of elderly men with late-onset hypogonadism.

Links
Publisher Full Text

Authors

Köhn FM, Schill WB

Institution

Department of Dermatology and Allergology, Technical University, Biedersteiner Strasse 29, 80802 Munich, Germany. Frank.Koehn@lrz.tu-muenchen.de"

I do admit to being not an overly clever person…
A lot of this stuff is doing my head in trying to understand it. But the more I look at these caps as a solution for TRT the better they are looking…

If they are not shutting you down completely then perhaps you don’t need hCG or arimidex?
They appear to work well and do what they are designed too…
Why bother with the injections if TRT is your goal?

"Andriol (testosterone undecanoate)

Feb 21, 2009

Tags:
bodybuilding
,
estrogen conversion
,
mild muscle gains
,
mild side effects
,
performance enhancing drugs
,
Profile of the oral steroid compound Andriol
,
testosterone undecanoate

Testosterone undecanoate

Andriol; 17-[(1-Oxoundecyl)oxy]-androst-4-en-3-one

Molecular Formula C30H48O3
Molecular Weight 456.70
CAS Registry Number 5949-44-0
EINECS 227-712-6

Andriol is an oral steroid that produces mild gains and extremely mild unwanted side effects. Unfortunately, it is also an expensive steroid and to make it worthwhile for athletes and bodybuilders to see results from its use, a lot needs to be taken.

Andriol is a unique oral testosterone product, developed by the international drug firm Organon. One of the more recently developed anabolic steroids, Andriol first became available in the early 1980′s. This compound contains 40 mg of testosterone undecanoate, based in oil (oleic acid) and sealed inside a capsule. Subtracting the ester weight, this equates to a dosage of approximately 25mg of raw testosterone per cap. The design of this steroid is quite different from that of most oral steroids. Drugs administered orally generally enter the blood stream through the liver. When a steroid compound is given this way without some form of structural protection, it will be quickly broken down during the ?first pass?. This process leaves very little steroid intact, basically deactivating the drug. Adding a methyl group (c-17 AA) to the structure is one way to protect it from this process, however stress is also placed on the liver as a result. In some instances this stress can lead to actual damage to liver tissues, so the designers of this steroid sought another way to protect the testosterone molecule. With Andriol, this was accomplished by making a form of testosterone that would be absorbed through the lymphatic system. This is due to its high fat solubility brought about by the ester, and its suspension in oil. Having the compound absorbed this way was thought to be very advantageous, as it allows the steroid to bypass the destructive first-pass through liver. This should permit the compound to enter the blood stream intact, without the need for a harsh chemical alteration. The ester breaks off once it is in circulation of course, yielding free active Pharmacokinetics of Oral Testosterone. In design this steroid appears to be undecanoate that of a completely liver safe and orally active form of testosterone.

On paper this drug seems like a great oral testosterone product. Clean, safe and worlds apart from other oral testosterone derivatives like the crude methyltestosterone. But as we always hear in life, if it looks to good to be true, it probably is. There are definitely some issues with Andriol. The first problem is that bioavailability, although clearly worlds apart from trying to take straight testosterone orally, is probably not significant next to c17alpha alkylated orals. Athletes typically find that in doses of less than 240mg per day (6 capsules) effects are generally not seen at all. 240mg of testosterone ester daily, the primary male androgen, and only a meager effect. When doses go higher, maybe 8-10 capsules (320-400mg), new muscle growth is slight to moderate at best, but no incredible bulky gains are ever reported. Logic leads one to believe that only a little testosterone is making its way into circulation. Testosterone is a powerful hormone no matter what the ester or form of administration. If it were active in the blood stream, the results would have to be pronounced. When one injects an oil based testosterone ester like cypionate, a dosage of 400mg per week is more than sufficient to see results. 400mg Andriol per day should be packing on an incredible amount of mass. Where does it all go? Individual problems with absorption may play a role into things here. Clearly there is little to be said except that this drug is unpredictable in its ability to be absorbed and utilized by the body. While one day you might be getting great absorption, perhaps the next day you are getting very little. Studies with men were no better than with women, where again this drug was shown to be unpredictably absorbed and utilized with blood levels ranging from 11.5 to 60.1 nmol/L with 80mg twice daily.

One might also pay interest to the ?mildness? of this compound as described by other bodybuilding materials. Andriol is often spoken about as some type of magic product, which to spite being a form of regular testosterone somehow allows for only minimal estrogen conversion. You should know that the way a drug is administered includes a number of factors that can slightly alter its effect, the most predominant being the speed of release. This effects the time it takes for a peak blood level to be reached, and likely the length it takes to see results. The primary reason Testosterone suspension seems more powerful than enanthate is because more drug is active on day one. At the same time estrogen builds up faster and side effects become pronounced very quickly. The ester is also part of the total weight, and 100mg testosterone contains a much larger quantity of testosterone molecules that testosterone plus ester, another reason for varying effect. But these changes do not amount to all that much. The structure of testosterone is what allows it to break down into estrogen. The only way we can really prevent an androgen from converting to estrogen is to change the base molecule, not the ester. Once free in the blood stream we cannot prevent testosterone from being aromatized without interfering with the aromatase enzyme itself. The lack of results and side effects often reported with Andriol must be going hand in hand with poor absorption.

Most athletes today consider Andriol a very poor buy. I know other references do find use for this drug, which is defendable because some amount of steroid clearly does enter the blood stream in tact. Technically it is still an oral testosterone, and definitely does not carry the same liver-toxicity risks associated with most steroids designed for this type of administration. Those specifically looking for a mild oral at times do purchase this product, and occasionally are even satisfied with their results. But for most its high price and required high daily dosages usually causes them to avoided it when crossing it on the black market. Besides, if we want a mild steroid the last thing we really should shop for is a testosterone."

Still researching but haven’t read anything bad about them yet… :slight_smile:

Testosterone Undecanoate comes in capusles 40 mg capsules 60/bottle. This product comes under the names Androxon, Undestor, Restandol and Restinsol in Europe and South America. This agent is a revolutionary oral steroid. It is presented in little, oval- shaped, red capsules. Andriol is a unique steroid in that it is not an alpha alkylayted 17 steroid. This all but eliminates its hepatotoxicity.

Andriol is actually contained in a natural ester base, one, which is very easy on the body. This product’s advantageous properties are similar to other testosterones in that it promotes rapid strength and weight gains. It, like other testosterones, promotes the storage of glycogen as well as ATP. Andriol does not seem to exhibit the degree of LH and FSH suppression that is seen with other testosterones and androgens.

Aromatization is also minimal with this agent. All in all, Andriol seems to yield gains similar to other testosterone esters, while being safer to administer. This drug has a wide following in parts of Europe where it is available.

If it were around in the United States, it’s popularity would be comparable to oral Dianabol. Effective dosages seem to be in the area of 200 mg a day taken in divided dosages. Andriol is a safe oral steroid that does not suppress gonadotrophins.It is absorbed through the small intestine into the lymphatic system, no burden to the liver it is a natural ester added to a synthetic derivative which will nor change liver enzymes. No testicular shrinkage, no reduction on in spermatogenesis will occur with reasonable dosages. Cholesterol triglycerides and total lipids tend to be reduced with long term use of Andriol as opposed to elevated with most oral steroids.

Effective Dose: 4 - 10 caps/ day

Andriol / Testosterone Undecanoate
Description:
Andriol, is a unique version of testosterone undecanoate developed by Organon. This version of testosterone is based in oil and is sealed in a capsule to be taken orally. According to the manufacturer, this method bypasses the liver and enters the body as a fat through the lymphatic system. In theory this seems quite interesting, however, athletes find Organon’s claims don’t hold up well. In doses of less than 240mg per day effects are generally non-existent.

With higher doses, effects are small at best. This leads one to think most of the steroid is not making it to circulation. Generally, steroid users experienced with any strong anabolics will be disappointed with Andriol’s results. Combined with other anabolics it may lend some effectiveness but should be questioned.

hey can u tell me a bit of ur experience with this form of test, ive researched it but would love to hear ur personal experience on how many u take and how it ends up being cost wise. I think its a very nice option, never heard of anyone being on it for that long without a break, but we are all built differently, many time I dont break between cycles with no adverse effects. thanks