You can have steadier levels self injecting 50mg twice a week. You can use $29 1/2" 0.5ml insulin syringes. These are around $14.00 at Sam's/Walmart, their Relion house brand. Inject IM into quads or SC over same. Many jurisdictions allow those syringes without a script.
Transdermals have the highest potential for T-->E2.
I often find issues in "normal" lab work.
Any thyroid tests? TSH, T3, T4, fT3, fT4?