Indian J Exp Biol 1995 Mar;33(3):194-200 Related Articles, Books
Protective effect of testosterone against alcohol and paracetamol induced hepatotoxicity in rats.
Jaya DS, Augstine J, Menon VP.
Department of Biochemistry, University of Kerala, Kariavattom, Trivandrum, India.
Chronic ethanol and paracetamol consumption, both individually and in combination, caused hepatic changes in rats. Treatment of testosterone (2.5 mg/kg body wt.) to the alcoholic and paracetamol administered rats showed decreased activities of serum transaminases, serum acid and alkaline phosphatases, and decreased levels of hepatic triglycerides, cholesterol and free fatty acids. Concentration of the lipid peroxidation product-malondialdehyde was significantly decreased in the liver after testosterone treatment in alcohol and paracetamol administered groups. Histopathological observations further confirm that testosterone could offer protection against alcohol and paracetamol induced damage to liver in animals.
I rediscovered this abstact today and I was curious if you guys think males suffering from less liver disease than females may be in part due to our higher test levels?