Sorry I’m late to the party. Good topic and that’s why I made this topic:
Problem with answering this question is no one really knows how T:SHBG interaction really works and there’s no harmonized methods for measuring free T. You’ve got a lot of people throwing out their fT numbers and have no idea the inherent limitations on the test. Their Doc doesn’t really get it either.
Free Hormone Hypothesis still very much an active area of research and I sure can’t answer your question. What drives adrenergic effect of T on the heart? TT or fT.
Is T bound to SHBG biologically active? I believe the answer is yes.
Is TT or fT concentration the driver for conversion to E2?
How many guys go to the trouble of collecting time based data points to estimate their effective clearance rate for TT or know their peak/trough on a particular dosing regimen?
Plot my cycle or whatever other website guys use now ain’t going to give you the plot above.