Test Cyponaite vs. Bio-Identical Pellets

Seen it. Prescribed by GPs.

Did you take 7mg daily at one point?

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No serious. 60mg weekly shot me to 1150. I was just as surprised. I thought I must be over dosing but my draw is 0.3ml twice a week. My urologist said if I did not reduce I would have a stroke so he got my attention.

That would be 120 mg/week at concentration stated above. There appears to be a consistent missing factor of 2 in this thread I am not understanding.


120 mg/week or 60 mg/week?

1150 ng/dl E3.5d trough?


Standard Rx guideline is once weekly dosing.

Very different dosing in TRT vs TOT land.

Starting Dose and Dose Adjustment

The starting dose of Xyosted is 75 mg, administered subcutaneously in the abdominal region once a week.

Dose adjustment

Measure total testosterone trough concentrations (measured 7 days after the most recent dose) following 6 weeks of dosing, following 6 weeks after dose adjustment, and periodically while on treatment with Xyosted. A trough concentration between 350 ng/dL and 650 ng/dL generally provides testosterone exposures in the normal range during the entire dosing interval.

Decrease the dose by 25 mg if the total testosterone trough concentration (Ctrough) is ≥650 ng/dL.
Increase the dose by 25 mg if the total testosterone Ctrough is <350 ng/dL.
Maintain the same dose if the total testosterone Ctrough is ≥350 ng/dL and <650 ng/dL.

Completely consistent with good ole chart:

This never gets old:

This is my original instructions from my provider. I backed down to 0.3ml, see below. There were instructions for sub q self injections that I did not include.

“I will send in a prescription for Testosterone Cypionate to your pharmacy. Depending on the dose this will last up to 3 months. I have also attached a coupon as your insurance is unlikely to cover the medication.

  1. Clean top of vial with alcohol. Use alcohol pads liberally, clean everything!

  2. The typical dose is 0.4 ml twice weekly like Sunday and Wednesday. Be super accurate with measuring this so you don’t run out early.

  3. Clean skin site well, abdominal wall is the best site. Site will get sore over the next 24 hours but nothing major. Move the site around to different areas of the abdomen with each administration”.

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Okay. I see the issue. There have been a few of these threads now. Substitute the word bioidentical with physiologically pulsed testosterone and it makes more sense.

See here for more info:

By your math, 0.15ml is equal to 30mg. Twice a week is 60mg. If that is the case, that explains the 1150 for sure. She explained it was to be a TOTAL of 80mg per week, not per dose. I asked for 80mg per week not 160….or 120.

0.3 ml twice weekly is 120 mg/week of test ester.

0.4 ml twice weekly is 160 mg/week of test ester.

Given these instructions and dosing there is nothing surprising with your TT result (taken at trough?).

Guess not…backing it down some

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Yeah, but that was daily injections and that only got me 425 ng/dL.

More nonsense. Do yourself a favor, don’t believe everything your doctor tells you about all things TRT.

Right, that is what I stated.

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A new guy coming in would definitely think you guys together are comedy genius. You are playing the straight man really well.



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My point is @Moneyman1 is not on a daily protocol, he’s talking about a twice weekly protocol if I’m not mistaken.

That’s hardly a close comparison. The difference in mg release is vastly different between the two protocols.


Geez, you’re killing me.

Try this, my point was that one guy (that would be you, smooth and steady) on this forum who at one time raved about taking a ridiculously low dose is criticizing another guy for taking a ridiculously low dose.

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For comparison, taking 26mg/day (daily Test C injections) got me to 1264ng/dL…

425/7mg=60.7ng/dL/mg response.
1264/26mg=48.6ng/dL/mg response.

Pretty close, albeit my SHBG is hella low which could explain a fair bit of that 2-person pool variation. That and the diminishing returns presented by higher doses of test.

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What I hate most and simply don’t understand, is why TRT has been so demonized by the PCP community almost at large. Even a vast number of endocrinologist do the same. To my knowledge, men are not dropping over dead in droves. I do see guys at my gym that are clearly abusing some sort of roid, but really?

Because of stuff like this:

Drug Safety Communication: FDA cautions about using testosterone products for low testosterone due to aging

FDA Drug Safety Communication: FDA cautions about using testosterone products for low testosterone due to aging; requires labeling change to inform of possible increased risk of heart attack and stroke with use | FDA

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It’s confirmation bias, urologists in medical school are taught high testosterone causes, fuels prostate cancer and therefore TRT was contraindicated for men with prostate cancer.

In the light of new evidence, some percentage of the medical community cannot unlearn what they have learned.

Then you got all the studies saying TRT doesn’t cause cardiovascular problems and other studies showing it does.

There’s a ripped guy at work who told me that TRT causes heart problems and I had to set him straight. So it’s not just the medical community, it’s a society problem, a media problem.

This is incorrect. I’m amazed at how many doctors know nothing about hormone treatment

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