48 year old white male. Lifelong athlete (wrestler, Brazilian Jiu-jitsu, swimming). 6 feet tall, 220lbs. Was pure vegetarian for first 35 years of life (no meat/fish/eggs). Now eat meat/fish/eggs.
About 2 years ago, came down with crippling pain in hips, knees, shoulders and neck. Diagnosed with “Polymyalgia Rheumatica” and “Rheumatoid Markers”. Placed on high-dose prednisone for almost 18 months. In words of Wellness Doctor, “That dose is really going to do you in, negatively impact your kidneys and liver and surge your cortisol. It will be a long road to recovery just from the side-effects of the prednisone, and it will also impact the value of your TRT.” Went up to 250lbs while on prednisone. Giant gut. Been off that now for over 6 months and back to normal weight. Pain is gone, Polymyalgia and Rheumatoid issues are “cured”.
Been on TRT (specifically, Testosterone Cypionate 2,000mg/10mL injectable only) since July of 2018 under the supervision of a Health & Wellness Consultant who is an MD. I get a full blood panel done every 3-5 months.
Additional supplements include: hydrolized gelatin (2,000mg/day), DEHA (25mg/day), Magnesium Chelate compound (1,200mg/day), CoQ10 (100mg/day), Vitamin D (5,000IU/day), Metformin (1,000mg/day), Aged Garlic Extract (1,200mg/day), Vitamin B12 (5,000mcg), hydration protocol of 120oz of water/day.
Daily exercise (weight lifting and Kettlebells) good; overall activity could be improved (more walking, wrestling).
Diet not as clean as it could be, though, I’ve discovered that near-elimination of grain-based carbohydrates is very favorable to my gut and reduces fatigue.
2018 bloodwork showed my T levels as:
TOTAL T = 216
FREE T = 4.0
Original T dose in July 2018 was 0.5cc @2x/week injectable, total 1cc/week.
By July 2019, 1 year later, T-levels were consistently above 900.
July 2019 blood panel shows T levels at:
TOTAL SERUM = 1090
FREE = 34.7
Cycled off/tapered off to take a “T vacation” and used HCG for several months, then went back on the same injectable Testosterone Cypionate 2,000mg/10mL at the same dose (0.5cc @ 2x/week, total of 1cc/week).
June 2020 blood panel showed T levels at:
TOTAL = 644
% FREE DIALYSIS = 3.5
FREE SERUM = 225
SERUM = 643
Doctor reduced T dosage to 0.25cc @ 2x/week, total of 0.5cc/week.
February 2021 blood panel showed T levels at:
TOTAL = 421
% FREE DIALYSIS = 3.0
FREE SERUM = 126
SERUM = 507
Doctor said, “Your T is a bit low. I’d like you to ‘live’ around 600.”
Doctor then increased T dosage to 0.25cc @ 3x/week for total of 0.75cc/week.
PROBLEMS: Feb 2020 blood panel revealed
(1) High cholesterol, specifically:
LDL-P = 1904
HDL-P = 34.4
SmallLDL-P = 827
(2) High Insulin Resistance Markers, specifically:
LP-IR SCORE = 82
(3) High Creatinine, specifically:
CREATININE = 1.37
Doctor’s exact quote, “That level of cholesterol tells me that it is very likely the particles are sticking to your artery walls. That cholesterol, in combination with your Insulin Resistance score is a recipe for heart disease and stroke. The high creatinine level also tells me your kidneys are taking a beating. If this doesn’t change by your next blood panel, I’m sending you to a Kidney Specialist. Move to a more plant-based diet, reduce your red meat consumption, and start drinking tons of water” (hence my hydration protocol above). That was VERY unsettling news as I imagined myself to be a person in excellent health. Freaked out for a little bit.
(1) If T use enhances cholesterol, why did he increase my dose to 0.75cc/week?
(2) Many holistic nutritionists (Chris Kresser is my primary example here) do not frown on cholesterol. Moreover, they say that eating foods high in cholesterol do not cause cholesterol surges in the bloodstream. They claim cholesterol is intimately related to insulin levels and that the worst thing one can do is be on a high-fat/high-protein diet that includes grain based carbs. Their solution is to eliminate grain-based carbs. I had done that previously and felt great. Thanksgiving and Christmas did me in and I went full-steam ahead on the grains. As of Feb 2020, I’ve eliminated them again and am already feeling better. How might the cholesterol/diet/T leves/insulin be related to one another?
(2) I don’t want to do 3 injections per week. Can I do 0.5cc for my first injection and then 0.25 for my second injection?
(3) There is a large discussion to be had about half-life here. We can get into that, but, it will impact the “spacing” of my 2x weekly injections. What’s the best schedule for 2x/week?