Support and fortify your sex organs and urinary tract so you can pee better and sex it up better.
Biotest had an objective. We wanted to create a supplement that supports the health of the prostate and the urinary tract and improves overall sexual health and function. Our list of goals was ambitious:
- Promote healthy prostate size and function
- Help manage oxidative stress and inflammation
- Support healthy urination and bladder emptying
- Help protect prostate cells
- Promote healthy hormone metabolism in the prostate
- Help maintain already healthy PSA levels
- Promote better blood flow to the penis
- Help improve sperm quality and motility
- Support healthy urinary flow
- Help protect urinary tract surface and lining
In short, we wanted to make a supplement that would fortify your genitourinary health so you could pee better and sex it up better. And it wouldn’t just be for old guys who make too many trips to the bathroom or have erection problems, but also for younger guys who want to keep their prostate, penis, balls, and bladder functioning like they did when they were in their twenties.
So we scoured the literature. We consulted experts. We noted the mistakes and shortcomings of commercial “prostate support” supplements and took note. We found out what worked and what didn’t.
Our labors resulted in a shortlist of three pretty impressive natural substances, each with a mountain of research behind it, and each chosen for how successfully it might fulfill the goals listed above. Then we sourced the highest quality, most concentrated forms of all three and combined them to make Biotest’s P-Well formula:
- Punicalagins (from pomegranate whole fruit extract)
- Lycopene (from natural tomato fruit extract)
- Cranberry whole fruit 50:1 concentrate
Here’s a quick run-down of what each of these ingredients is and what it’s purported to do:
Punicalagins are the large molecules responsible for much of the “magic” associated with pomegranates and pomegranate juice. They belong to a class of polyphenols known as ellagitannins that, once ingested, act in multiple ways. Some act directly as antioxidants, while others are metabolized by microflora in the gut to form potent compounds such as ellagic acid and urolithins.
What’s hugely compelling about them is that a large number of in-vitro, animal, and human studies have suggested they might play a significant role in the health of the human genitourinary tract. Among the positive findings of assorted pomegranate and punicalagin studies are the following:
- Helps manage reproductive inflammation
- Promotes healthy prostate size and function
- Supports healthy hormone metabolism in the prostate
- Helps maintains already healthy PSA levels
- Promotes better blood flow to the penis
- Supports healthy urinary flow
Lycopene is a red carotenoid pigment that gives tomatoes, watermelons, and pink grapefruit their characteristic color. Lycopene has over 2,000 peer-reviewed studies dedicated to it, making it one of the most studied plant chemicals ever.
Even though its health-promoting effects are diverse, lycopene specifically fortifies male reproductive health in the following unique ways:
- Helps protect prostate cells from oxidative stress
- Promotes improved sperm quality and motility
Cranberries contain a variety of plant chemicals with positive effects on the urinary tract. This is especially true with a strong cranberry concentrate like that found in the P-Well formula.
Multiple studies show cranberry, especially cranberry concentrate, sustains the health of the muscles that control the bladder and provides the following important advantages for the urinary tract:
- Promotes healthy urination and bladder emptying
- Helps protect urinary tract surface and lining
The P-Well supplement is different from most formulas in that you probably won’t have to take it on faith that it’s working. Hopefully, it will show you it’s working by how it positively changes your life.
You might notice you have a stronger urine stream and a more efficient emptying of the bladder. You could also enjoy a better sex life with more blood flow into the penis.
Lastly, and perhaps most importantly, P-Well supports the overall health and function of the all-too-vulnerable prostate.
- Sharma P et al. **Pomegranate for Prevention and Treatment of Cancer: An Update.**Molecules. 24 January 2017.
- Vicinanza R et al. Pomegranate Juice Metabolites, Ellagic Acid and Urolithin A, Synergistically Inhibit Androgen-Independent Prostate Cancer Cell Growth via Distinct Effects on Cell Cycle Control and Apoptosis. Evidence Based Complementary and Alternative Medicine. 19 February 2013.
- Wang L et al. Cellular and molecular mechanisms of pomegranate juice-induced anti-metastatic effect on prostate cancer cells. Integr Biol. 2011 May 19.
- Chaves FM et al. Pomegranate Juice and Peel Extracts are Able to Inhibit Proliferation, Migration and Colony Formation of Prostate Cancer Cell Lines and Modulate the Akt/mTOR/S6K Signaling Pathway. Plant Foods Hum Nutr. 2020 March;75(1):54-62.
- Kroeger N et al. Pomegranate Extracts in the Management of Men’s Urologic Health: Scientific Rationale and Preclinical and Clinical Data. Evid Based Complement Alternat Med. 2013 Mar 26.
- Forest CP et al. Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-controlled, double-blind, crossover study. Int J Impot Res. Nov-Dec 2007;19(6):564-7.
- Jeranka JS. Therapeutic Applications of Pomegranate (Punica granatum L.): A Review. Alternative Medicine Review: A Journal of Clinical Therapeutic, July 2008,13(2):128-44.
- Gur S et al. Characterisation of pomegranate juice effects on human corpus cavernosum. Andrologia 2017 Oct;49(8).
- Azadzoi K et al. Oxidative stress in arteriogenic erectile dysfunction: prophylactic role of antioxidants. J Urol. 2005 Jul;174(1):368-93.
- Deng Y et al. The extract from Punica granatum (pomegranate) peel induces apoptosis and impairs metastasis in prostate cancer cells. Biomed Pharmacother. 2017 Se9;93:976-984.
- Bassiri-Jahromi S. Punica granatum (Pomegranate) activity in health promotion and cancer prevention. Oncol Res. 2018 Jan 30;12(1):345.
- Chrubasik-Hausman S et al. Pomegranate juice and prostate cancer: importance of the characterisation of the active principle. Phytoter Res. 2014 Nov;28(11):1676-8.
- Wang L et al. Pomegranate and Its Components as Alternative Treatment for Prostate Cancer. Int J Mol Sci. 2014 Sep; 15 (9):14949-14966.
- Amri Z et al. Growth Inhibitory and Pro-Apoptotic Effects of Ornamental Pomegranate Extracts in Du145 Human Prostate Cancer Cells. Nutrition and Cancer. Volume 72. 2020. Issue 6.
- Chen P et al. Lycopene and Risk of Prostate Cancer. A Systematic Review and Meta-Analysis. Medicine (Baltimore). 2015 Aug;94(33): 31260.
- Lane JA et al. ProDiet: A Phase II Randomized Placebo-controlled Trial of Green Tea Catechins and Lycopene in Men at Increased Risk of Prostate Cancer. Cancer Pres Res. 2018 Nov;11(1): 687-696.
- Wang Y et al. Lycopene, tomato products and prostate cancer-specific mortality among men diagnosed with nonmetastatic prostate cancer in the Cancer Prevention Study II Nutrition Cohort. Int J Cancer. 2016 June 15;138 (12):2846-55.
- Vidlar A et al. The effectiveness of dried cranberries ( Vaccinium macrocarpon) in men with lower urinary tract symptoms. Brit J Nutr, 2010 Oct;104(8):118-9.
- Wang CH et al. Cranberry-Containing Products for Prevention of Urinary Tract Infections in Susceptible Populations: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Arch Intern Med. 2012;172(13):988-996.
- Luis A et al. Can Cranberries Contribute to Reduce the Incidence of Urinary Tract Infections? A Systematic Review with Meta-Analysis and Trial Sequential Analysis of Clinical Trials. The Journal of Urology. Volume 3 198. Issue 3. September 2017. Pages 614-621.