T Nation

T Treatment / Prostate Cancer

Testosterone Treatment Linked With Prostate Cancer

Prostate cancer developed in 20 men within months to a few years after they began testosterone supplementation to correct a deficiency of the hormone, investigators report. “There are several anecdotal case reports, small studies, and observational studies like ours which raise concern but do not provide conclusive evidence yet,” Dr. Franklin D. Gaylis told Reuters Health. The issue is a concern because prostate cancer is usually driven by testosterone. Gaylis, from the University of California at San Diego Medical Center, and colleagues report this series of patients “in whom clinically significant prostate cancer developed and was presumed to be related to exogenous testosterone use,” in the Journal of Urology.

See rest of story here: http://today.reuters.com/news/newsArticle.aspx?type=healthNews&storyID=2005-08-12T193750Z_01_MCC270596_RTRIDST_0_HEALTH-TESTOSTERONE-TREATMENT-CANCER-DC.XML

This needs to be taken with a grain of salt.

Another recent long-term study with long-term T treatment of men around 70 years old found a higher rate of BPH in the control group than in the treatment group over a two-year observation period (Hajjar, et al, 1997).

And saying prostate cancer is “usually driven by Testosterone” is a little misleading. it would be more accurate to say that prostate cancers seem to be driven by DHT, a byproduct of Testosterone,in which case you could take finasteride, dutasteride, or even Biotest’s M.

And, there’s some evidence that the most virulent prostate cancers are driven by estrogen, or that at least estrogen acts synergistically with DHT in causing BPH.