Suggest that you get a quick lab for TT, FT and E2 in 2-3 weeks to help get your dosing right.
Anastrozole dose needed to match serum T levels and when that dropped E2 production would drop plus the anastrozole dose was too much for that; so E2 gets even lower. This confirms not a simple lab error.
140mg may not be enough, when we see this problem, it seems that the few that we have seen here so affected needed 300mg/week. Those guys have not stood out with any obvious complicating issues that I have noticed.
I think that the explanation would have to be something involving the liver.
And see if you can try a different brand of T to see if that affects the injection site issues.