T Nation

Synergy of Steroids

Already the great knowledge that you can build powerful cycles combining different drugs instead of choosing just one drug, and there are numerous ways to mount a cycle efficiently based on the principle of synergy. In this article I will further explore this idea, so that make a cycle smart and powerful it becomes easier.

Anabolic steroids can be grouped in different ways according to their distinct characteristics and similarities. We can group them by families, classes (Bill Roberts), activity (progestins, 17aa, SHBG, etc.), purpose (cutting, bulk). Knowing each group makes it easy to understand why certain combinations of steroids are very powerful, while others may make your cycle a failure (though in high doses cycles inefficient work anyway, and this is very common even among elite athletes).

  1. PURPOSE (Bulk, Cutting):
    I prefer not to distinguish this group of steroids since you can adjust the use of certain drugs according to other methods that use during the steroids cycle (aromatase inhibitors, diet). So it is essential to know the profile of each drug before starting a steroids cycle and ride it the most efficient way to your goal. The key here is how much water retention and fat burning will be a concern for you. Knowing this you will know that drugs choose.

    Anabolic steroids can be divided into 3 distinct families, according to their direct derivation (testosterone, nandrolone or DHT), and this division is very important to know the characteristics that unite and separate the different families of drugs. Knowing this is clear because you increase the risk of side effects often when combining drugs of the same family (test + D-bol, deca + fina) and can also decrease the effectiveness of the steroids cycle, but can also increase it by combining drugs from different families (Test + winstrol + fina). But this only becomes clear when other principles of synergy are also known.

Testosterone and its esters: suspension (no ester attached test), testosterone of short half-life (propionate, phenylpropionate), test of long half-life (enanthate, cypionate, decanoate), mix of esters (Sustanon, Omnadren), dianabol, Boldenone, Halotestin, Turinabol.

b) 19-NOR:
Nandrolone and esters (phenylpropionate, deca), trenbolone (acetate, enanthate).

Anadrol, oxandrolone, stanozolol, primobolan, masteron, proviron.

  1. CLASS 1 and 2:
    Whereas testosterone as the steroid base with powerful synergy with all other types and families of steroids next step is how to combine other drugs in the construction of a cycle more efficient than using a random combination. Many guys throw drugs at random in a steroids cycle and will not fail to have good results, but in general it is often unnecessary and a huge waste.
    Steroids can divide into two classes, 1 and 2. We call class 1 steroids which has a strong connection to the androgen receptor (AR), Class 2 and those with weak binding to the AR (independent anabolic effect), and its action is regulated by other receptor types.
  • Class 1: trenbolone, deca, primobolan, Boldenone, Oxandrolone, Masteron, Turinabol.
  • Class 2: Dianabol, Anadrol, stanozolol, Halotestin
    Steroids have different mechanisms of action in the body and combining drugs with similar activities you can increase or decrease the positive and negative effects (side effects) of the cycle.

a1) Aromatization:
The process of conversion of testosterone to estrogen, which can cause various side effects such as retention, gynecomastia, high blood pressure, etc… Aromatizing drugs: testosterone, deca, dianabol, boldenone.

a2) Anti-estrogenic:
These drugs have anti-estrogenic activity, avoiding side effects related to increased estrogen by aromatization of other drugs: masteron, primobolan, proviron, stanozolol (?).

b1) Progestins:
These drugs cause effects on its progestenic activity and may elevate prolactin levels and cause side effects such as gynecomastia, severe inhibition of the HPTA. Examples: Anadrol (a progestin is not considered directly, but seems to have some kind of progestenic activity), deca, trenbolone.

b2) Anti-progestenics:
These drugs have anti-progestenic activity, avoiding or reducing side effects related to progestenic activity of progestins. Example: stanozolol.

c) 17aa steroids:
Nearly all steroids cause liver damage, whereas the 17aa are more toxic to the difficulty of processing (for surviving first pass through the liver). That way we all know that is not interesting combine hepatotoxic drugs or use them for a long period. The most hepatotoxic steroids are anadrol, dianabol, methyltestosterone, Halotestin, stanozolol, while oxandrolone and Turinabol are considered 17aa of low hepatotixicty.

d) Reduction of SHBG:
An important mechanism of action of some anabolic steroids often ignored by most users, is in its ability to reduce levels of SHBG (Sex Hormone Binding Globulin). Testosterone unbound (free) has biological activity while bound to SHBG is inactive. The SHBG acts as a modulator of secretion androgenic in tissues. Thus, lower levels of SHBG increases the availability of androgen action, since they fail to bind thereto. So if you do only one testosterone cycle and SHBG levels are high you lose effectiveness of steroids cycle, since part of the testosterone will bind to SHBG. You can increase the efficiency of the cycle added a drug that reduces SHBG, and other additional effects of the drug logically. Examples of steroids that significantly reduce SHBG: stanozolol, Turinabol, proviron, anadrol.

Now you have the key ingredients to building a powerful cycle.